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1、乌饭树树叶及其提取物对视网膜光损伤的保护作用第27卷第3期2006年6月西安交通大学(医学版)JournalofXi'anJiaotongUniversity(MedicalSciences)Vo1.27N0.3Jun.2006乌饭树树叶及其提取物对视网膜光损伤的保护作用王立,张雪彤,姚惠源(1.江南大学食品学院,江苏无锡214036f2.无锡第四人民医院眼科,江苏无锡214036)摘要:日的研究乌饭树树叶及其提取物对视网膜免受光损伤的保护功能.方法将2O只新西兰白兔分成4组:正常对照组和模型对照I,Ⅱ,Ⅲ组.正常对照组动物自由摄取饲料,自由饮水;模型对照I,Ⅱ,Ⅲ组动物除自由摄取
2、饲料,自由饮水外,每天分别喂乌饭树新鲜树叶[50g/(kg?d)],乌饭树陈旧树叶[50g/(kg?d)]和乌饭树树叶提取物[50mg/(kg.d)],连续4周.并且进行强光刺激,同时利用视网膜电图(ERG)进行视网膜分析,最后处死白兔测定视网膜中丙二醛(MDA)的含量和总超氧化物岐化酶(T-SOD)的活力.结杲ERG测定结果发现,对照组B波的潜伏期时间延长而振幅降低,模型组白兔ERG的变化趋势正好相反.同时模型组视网膜中的MDA含量要低于对照组(P<O.01),而SOD含量则高于对照组(P<O.01).结论服用乌饭树树叶及其提取物对眼睛视网膜具有明显的保护作用.关键词
3、:乌饭树;提取物;视网膜;光损伤中圈分类号:R774文献标识码:A文章编号:1671—8259(2006)03—0284—04TheprotectiveeffectofVacciniumBracteatumThunbleavesandtheextractagainstlightinjuryofretinaWangLi,ZhangXuetong,YaoHuiyuan(1.SchoolofFoodScienceandTechnology,SouthernYangtzeUniversity,Wuxi214036;2.DepartmentofOphthalmologyoftheWuxiNo
4、.4People'SHospital,Wuxi214036,China)ABSTRACT:ObjectiveToinvestigatetheprotectiveeffectoftheextractofVacciniumBracteatumThunb(VBT)leavesagainstlightinjuryofretina.Methods20Newzealandrabbitsweredividedinto4groups:thenormalcontrolgroup,modelIgroup,modelIIgroup,andmodelⅢgroup.Thenormalcontrolgroup
5、ateanddrankfreely.modelIgroupateanddrankfreelybuttookin50g/(kg?d)freshVBTleavesdailyfor4weeks.modelIIgroupateanddrankfreely,buttookin50g/(kg?d)oldVBTleavesdailyfor4weeks.modelⅢgroupatefreely,buttookin50mg/(kg?d)extractofVBTleaves(resolvedinwater)dailyfor4weeks.Allrabbitswereexposedtostrongligh
6、t,meanwhile,theretinaswereanalyzedbyelectroretinogram(ERG)everyweek.Finally,alltherabbitswerekilledandthecontentofMDAandSODintheretinaweredetected.ResultsInthecontrolgroup.thelatencytimeoftheBwaveincreasedandtheamplitudeoftheBwaveshortened,whileinthemodelI,IIandmgroups,thechangesofBwavejustopp
7、osite.ThecontentofMDAinthemodelI,II,andⅢgroupswaslowerthanthatinthecontrolgroup(P<0.01),butthecontentofSODinthemodelI,II,andⅢgroupswashigherthanthatinthecontrolgroup(P<0.01).ConclusionTheleavesofVBTandtheextractcanprotecttheretina
