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1、SpecificBacteriologyLearningObjectives(referencedtoMurray’stextbookwhererelevant)1.BacterialStructure,Physiology&Classification(Chapters2,3,4;Dr.Yother’soutline)A.Compareandcontrastthepropertiesofeukaryotesvs.prokaryotes.(p.11,Fig.3.1)EukaryotesProkary
2、otesAnimal,plantandfungiBacteriaandbluegreenalgaeTruenucleusPrimitivenucleus80sribosome70sribosomeDNAdiploidstrandsSinglecircularhaploidDNAHaveorganellesLacknucleusandorganellesExtrachromosomalDNAinorganellesExtrachormosomalDNAinplasmidsNocellwall(exce
3、ptfungi)Peptidoglycancellwall(most)SexualandasexualreproductionAsexual/binaryfissionRespirationviamitochrondriaRespirationviacytoplasmicmembraneSterolsusuallypresentSterolsabsentB.Compareandcontrastcellwallcomponentsingram-positivevs.gram-negativebacte
4、ria.(p.12-24)GramPositive:thickpeptidoglycanlayercontainingwallteichoicacid(WTA)covalentlylinkedtopeptidoglycanandlipoteichoicacids(LTA)membraneanchored,notcovalentlylinkedGramNegative:thinpeptidoglycanlayer,outermembranecontaininglipopolysaccharide,ph
5、ospholipids,andproteins.Periplasmicspacebetweencytoplasmicandoutermemcontainstransport,degradativeandcellwallsyntheticproteins.Outermemisjoinedtothecytoplasmicmematadhesionpointsandisattachedtopeptidoglycanbylipoproteinlinks.C.Understandstructureandfun
6、ctionofeachbacterialmajorultrastructuralcomponent:chromosome,plasmid,ribosome,inner(cytoplasmic)membrane,outermembrane,mesosome,teichoicacid,peptidoglycan,lipopolysaccharide,capsule,pili,flagella,endospores.(p.12-22).Chromosome:single(haploid)doublestr
7、andedcirclenotcontainedinnucleusbutdiscreteareacallednucleoid,nohistones,nonucleosomes,600-4500kb,~1kb/genePlasmid:smaller,circularextrachromosomalDNAs,usuallyingramnegative,usuallynotessential:provideselectiveadvantage(antibioticresistance,metabolic,v
8、irulence,conjugative),fewtoseveralhundredkbRibosome:30s+50ssubunits,form70sribosome,translationofmRNAtoproteinCytoplasmicmembrane:lipidbilayerstructure,NOSTERIODS(exceptmycoplasmas),responsibleforelectrontransport,energyproduction,trans
