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1、ALLERGYCONTENTSPrefacexiAnthonyMontanaroGeneticsofAllergicDisease1JohnW.SteinkeandLarryBorishGeneticsprovidesthebasisforthehostresponsetoavarietyofenvironmentalfactorsthatcanresultincomplexgeneticdiseases,suchasasthmaandatopy.Anunderstandingofthegeneticbasisforthes
2、econditionsisessentialtounderstandtheirpathophysiol-ogy.Severalregionsofthehumangenomehavebeenreproduciblyassociatedwithasthmaandatopyandthefunctionaleffectsofthevariationintheseregionsarebeingelucidated.Itishopedthattheseandongoingstudieswillultimatelydefinenewtarg
3、etsforthenextgenerationofasthmaandallergytherapeutics.AllergicRhinitis:ImpactoftheDiseaseandConsiderationsforManagement17AlexanderN.GreinerAllergicrhinitisisacommonyetunderappreciatedinflammatoryconditionofthenasalmucosa.Thisarticlereviewscurrentconceptsofclassificat
4、ion,theimpactofthediseaseonqualityoflife,andas-sociatedconditionsandprovidesadetailedaccountofcurrentlyavailabletreatmentoptions.Asthma:DiagnosisandManagement39SameerK.MathurandWilliamW.BusseThediagnosisandmanagementofasthmacontinuetobeofcriticalimportance,asrecent
5、trendshavedemonstrateditsincreasingprevalence,morbidity,andperhapsmortality.Becausecurrenttreatmentsforasthmaareeffectiveandsafe,itisimportanttodiagnoseasthmaearlyandtousetreatmentseffectively,particu-larlythosedirectedtowardairwayinflammation.ThediagnosticVOLUME90Æ
6、NUMBER1ÆJANUARY2006viimeasuresandarrayofmedications,boththosecurrentlyavailableandonthehorizon,provideanarmamentariumforeffectivediag-nosis,management,andmonitoringofasthma.Incomingyears,itisexpectedthatadditionaltestingmodalitieswillbeavailableformoreprecisemonito
7、ringofasthmacontrol,andanincreasedunder-standingofpharmacogeneticswillenablethetailoringofasthmamedicationstospecificpatients,providingcustomizedtherapytomaximizeasthmacontrol.DifferentialDiagnosisofAdultAsthma61StephenA.TillesAsthmaisacommonsyndromethataffectsappro
8、ximately5%oftheadultpopulationintheUnitedStates.Thisarticlefocusesonthedifferentialdiagnosisofadultasthma,includingadiscussionofreasonableclinica
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