生物医学U3B资料.ppt

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1、生物医学U3BPara.1:TheeffectsofinflammationInflammation:thereactionofvascularizedtissuetolocalinjury.effectsofinflammation:UndesirableyetbeneficialPara.2:Thecausesofinflammationthecausesofinflammation:infectiousmicroorganisms,trauma,surgery,causticchemicals,extremesofheatandcold,ischemicdamagetotissue

2、sPara.3:Similarresponses“…initiatedbyavarietyofinjuriousagents...”initiate:cause/startsthE.g.Cardiovasculardiseasescanbeinitiatedbyafattydiet.油腻的饮食会引发心血管疾病。injuriousagents:损伤因子Para.4:Namingofinflammation-itisusedtodenoteaninflammationExamplesListofinflammationsBodypartBodypartAppendicitisAppendix

3、ArthritisJointBronchitisBronchiGastritisStomachNephritisKidneyPneumonitis/PneumoniaLungsHepatitisLiverPericarditisPericardiumneuritisnerveExamplesSigns:Rubor/rednessTumor/swellingCalor/heatDolor/painFunctiolaesa/lossoffunctionPara.5:Descriptionofacuteinflammationcardinalsignsofinflammation:发炎主征ag

4、eneralalarmandrecruitmentsystem:全身的报警和召集系统acute-phaseresponse:急性期反应plasmaproteins:血浆蛋白Para.6:ManifestationofacuteinflammationVascularresponseCellularbloodresponseThingsincommon:releaseofchemicalmediatorsinflammatoryexudatesThehemodynamicandwhitebloodcellresponsescontributetotheinflammatoryexudate

5、s,theextravascularinfluxoffluidcontaininghighconcentrationsofproteins,salts,cells,andcellulardebris.influx:thearrivaloflargenumbersofpeopleorlargeamountsofmoney,goodsetc,especiallysuddenly(>influxof)大量涌入血液动力和白细胞反应促使炎症渗出物的形成。它是从血管渗出流到炎症部位的体液，含有高浓度的蛋白质、盐、细胞、以及细胞碎片。Paras.7-9:vascularresponseHowdoest

6、hevascularresponseoccur?Whycanvascularresponsebenefitthehost?Whatarethethreetypesofvascularresponse?Process:Momentaryconstriction→vasodilation→congestion→redness/warmness→increaseincapillarypermeability→swelling→pain/impairedfunctionBenefit:DilutelocalizethreepatternsofvascularresponsesImmediatet

7、ransientImmediatesustainedDelayedPara.10:cellularresponseFeature:MovementofleukocytesintotheareaofinjuryTheselonger-livedphagocyteshelptodestroytheagent,aidsignalingofspecificimmunity,andservetoresolvetheinflammatorypr