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1、TrendsinGenomicDataAnalysiswithR/BioconductorLeviWaldronCUNYSchoolofPublicHealth,HunterCollegeMartinT.MorganFredHutchinsonCancerResearchCenterMichaelLoveDana-FarberCancerCenterVincentJ.CareyHarvardMedicalSchool16July,2014IntroductionsILeviWaldronISpecializations:datacurationandmeta-analysis,g
2、eneexpression,predictivemodelingIMartinT.Morgan:GenomicdataandannotationthroughAnnotationHubIBioconductorprojectleaderISpecializations:sequencedataanalysis,genomicannotationIVincentJ.CareyScalableintegrativebioinformaticswithBioconductorIBioconductorfoundingmemberISpecializations:eQTL,integra
3、tivegenomicdataanalysis,performantcomputingIMichaelLove:RNA-Seqwork
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4、analysisIdistributeddevelopmentIntroduction:BioconductorI1341PubMedfull-textcitationsintrailing12monthsI28,000webvisits/month;75,000uniqueIPdownloads/yearIAnnualconferences;courses;activemailinglist;...BioconductorConference,July30-Aug1,Boston,USABioc2014:July30-Aug1,2014(Boston)IJuly30:Devel
5、opersDay(currentandprospective)IMorningscienti ctalksIafternoonpracticals(2hhands-onsessions)IIntroduction,VariantCalling,IntroSequenceAnalysis,RNA-seqdi erentialexpression,ChIP-seq,450Kmethylationdataanalysis,genomicannotationresources,meta-analysis,parallelcomputing...https://register.bioco
6、nductor.org/BioC2014Introduction:ApplicationareasofBioconductorIMicroarrayanalysis:expression,copynumber,SNPs,methylation,...ISequencing:RNA-seq,ChIP-seq,calledvariants,...IEspeciallyafterassembly/alignmentIAnnotation:genes,pathways,genemodels(exons,transcripts,etc.),...IEpigeneticsIGeneseten
7、richmentanalysisINetworkanalysisIFlowcytometryIProteomicsandmetabolomicsICheminformaticsIImagesandhigh-contentscreensLevelsofdocumentationBioconductordocumentationexistsatseverallevels:Ihttp://www.bioconductor.org/helpIWork
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