玫芦消痤膏联合地氯雷他定治疗64例糖皮质激素依赖性皮炎临床探究.doc

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1、玫芦消瘗膏联合地氯雷他定治疗64例糖皮质激素依赖性皮炎临床探究［摘要］目的探讨玫芦消痙膏联合地氯雷他定治疗糖皮质激素依赖性皮炎的临床疗效。方法选择2009年2月〜2011年8月在我院皮肤科门诊就诊的64例糖皮质激素依赖性皮炎患者，将其随机分为两组，对照组（32例）口服5mg地氯雷他定，1次/d;研究组（32例）在对照组治疗的基础上加用玫芦消瘗膏局部外用，早中晚各1次。治疗1个月后进行临床疗效评价。结果治疗后研究组症状积分明显低于对照组，两组比较差异有统计学意义（P<0.05）,两组症状积分差值在治疗前后比较差异有统计学意义（P<0.05）。研究组

2、治疗有效率（84.38%）明显高于对照组的53.13%,两组比较差异有统计学意义（P<0.05）,并且没有明显不良反应发生。反弹现象研究组明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论玫芦消瘗膏联合地氯雷他定治疗糖皮质激素依赖性皮炎临床疗效确切，并且没有不良反应发生。［关键词］玫芦消痙膏；地氯雷他定；糖皮质激素依赖性皮炎［中图分类号］R758.2［文献标识码］A［文章编号］1673-7210(2012)07(a)-0080-02ClinicalinvestigationofMeiluxiaocuoCreamandDeslorata

3、dineinthetreatmentof64caseswithglucocorticoidsdermatitisWANGKaiSHANGYanhuaThePeople?sHospitalofSonggangDistriet,GuangdongProvince,Shenzhen518105,China[AbstTact]ObjectiveTostudytheclinicalcurativeeffectofMeiluxiaocuoCreamandDesloratadineinthetreatmentofglucocorticoidsdermatiti

4、s・Methods64caseswithglucocorticoidsdermatitiswereremdomlydividedintotwogroups(researchgroupandcontrolgroup),with32patientsineachgroup・ThecontrolgroupwastreatedwithDesloratadine(5mg,onceaday)・Onthebasisofthetreatment,theresearchgroupwasgivenMeiluxiaocuoCream(threetimesaday).Th

5、eclinicalcurativeeffectwasevaluatedaftertreatmentforonemonth.ResuItsThesymptomintegralofresearchgroupwassignificantlylowerthanthesymptomintegralofcontrolgroup,withstatisticallysignificantdifferences(P<0.05).Thesymptomintegraldifferenceofthetwogroupsbeforeandaftertreatmentwere

6、significantdifferent(P<0.05).TheeffectiveTateofresearchgroup(84.38%)wassignificantlyhigherthantheeffectiverateofcontrolgroup(53.13%),withstatisticallysignificantdifferences(P<0.05).Allcasesdidn?tappearadversereaction・Thereboundphenomenonofresearchgroupwassignificantlylowertha

7、nreboundphenomenonofcontrolgroup,withstatisticallysignificantdifferences(P<0・05).ConclusionMeiluxiaocuoCreamandDesloratadinehavesurecurativeeffectinthetreatmentofglucocorticoidsdermatitisandtheyhavenoadversereactions,theclinicalimplementationshouldbepromoted・[Keywords]Meiluxi

8、aocuoCream；Desloratadine；Glucocorticoidsdermatitis糖皮质激素依赖性皮炎是指因长期外用糖