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1、ViewArticleOnline/JournalHomepage/TableofContentsforthisissueCRITICALREVIEWwww.rsc.org/loc
2、LabonaChipCentrifugalmicrofluidicsforbiomedicalapplicationsabaaccdRobertGorkin,JiwoonPark,JonathanSiegrist,MaryAmasia,BeomSeokLee,Jong-MyeonPark,ccabbJintaeKim,HanshinKim,MarcMadouandYoon
3、-KyoungCho*Received16thNovember2009,Accepted3rdMarch2010FirstpublishedasanAdvanceArticleontheweb28thMay2010DOI:10.1039/b924109dThecentrifugalmicrofluidicplatformhasbeenafocusofacademicandindustrialresearcheffortsforalmost40years.Primarilytargetingbiomedicalapplications,arangeof
4、assayshavebeenadaptedonthesystem;however,theplatformhasfoundlimitedcommercialsuccessasaresearchorclinicaltool.Nonetheless,newdevelopmentsincentrifugalmicrofluidictechnologieshavethepotentialtoestablishwide-spreadutilizationoftheplatform.Thispaperpresentsanin-depthreviewofthecen
5、trifugalmicrofluidicplatform,whilehighlightingrecentprogressinthefieldandoutliningthepotentialforfutureapplications.Anoverviewofcentrifugalmicrofluidictechnologiesispresented,includingdescriptionsofadvantagesoftheplatformasamicrofluidichandlingsystemandtheprinciplesbehindcentrifug
6、alfluidicmanipulation.Thepaperalsodiscussesahistoryofsignificantcentrifugalmicrofluidicplatformdevelopmentswithanexplanationoftheevolutionoftheplatformasitpertainstoacademiaandindustry.Lastly,wereviewthefewcentrifugalmicrofluidic-basedsample-to-answeranalysissystemsshowntodateande
7、xaminethechallengestobetackledbeforethecentrifugalplatformcanbemorebroadlyacceptedasanewdiagnosticplatform.Inparticular,fullyintegrated,easytooperate,inexpensiveandaccuratemicrofluidictoolsintheareaofinvitronucleicaciddiagnosticsarediscussed.1.0Introductionmixingofreagentsormet
8、eringofsamplefluidscanbeautomatedsimplybyimplementingdifferentspinningprofiles.ThroughtheInthefieldofmicrofluidiclab-on-a-chipsystems,thecentrifugaladaptionofminiaturizationtechnology,multipleanalysisstepsmicrofluidicplatformhasemergedasanadvancedtechnologycanbeintegratedonasingled
9、isc,oftentowardsthedevelopmentforbiologicalanalysis.‘‘Lab-on-
