巴戟天对微波辐射致成年雄性大鼠睾丸损伤的作用

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1、CHINESEJ()URNALOFANATOMYVo1．37No．12014解剖学杂志2014年第37卷第1期巴戟天对微波辐射致成年雄性大鼠睾丸损伤的作用李容刘良财王凤娟。王玮。△(1泉州医学高等专科学校，泉州362011；2晋江市公安局刑侦大队，晋江362200；3福建医科大学解剖与组织胚胎学系，福州350108)摘要目的：探讨巴戟天对微波辐射致大鼠睾丸损伤的作用。方法：成年雄性SD大鼠随机分为空白对照组(不辐射，不给药)、辐射组(辐射，不给药)、阴性对照组(辐射，灌胃等体积双蒸水)、巴戟天水提物组(辐射，灌胃巴戟天水提物)和巴戟天醇提物组(辐射，灌胃巴

2、戟天醇提物)。应用对讲机辐射8h／d，辐射密度为300／,W／cm2，频率409MHz，持续2周。末次辐射后第2天，巴戟天水提物组和巴戟天醇提物组分别给以巴戟天水、醇提物20g·kg·d灌胃治疗，末次灌胃后禁食24h杀鼠取材比较各组问体质量、睾丸指数和附睾指数；左侧睾丸组织和附睾组织常规H—E染色后光镜下观察微细结构，右侧睾丸组织透射电镜观察超微结构。结果：各组间体质量、睾丸指数和附睾指数均无差异；辐射组睾丸和附睾微细结构可见病理改变，两个给药组恢复较好；辐射组睾丸超微结构可见损伤，两个给药组有不同程度修复。结论：巴戟天对微波辐射致成年雄性SD大鼠睾丸损伤

3、有修复作用。关键词巴戟天；微波辐射；雄性大鼠；睾丸EffectofMorindaofficinalishowonadultmalerats’testiculardamageinducedbymicrowaveradiationLiRong，LiuLiangcai，WangFengjuana，WangWei。△(j．QuanzhouMedicalCollege，Ouanzhou362011；2．CriminalInvestigationBrigadeofPublicSecurityBureau。Jinjiang362200；3．DepartmentofAna

4、tomyandHistologyEmbryology，FianMedicalUniversity，Fuzhou350108，China)AbstractObjective．ToexploretheeffectofMorinaofficinalishowonadultmalerattesticulardamageinducedbymicrowaveradiation．Methods：FortyadultmaleSDratswererandomlydividedintofivegroups，ablankcontrolgroup，amicrowavegroup，

5、anegativecontrolgroup，anaqueousextractofMorindaofficinalishowgroupandalcoholextractofMorindaoficinalishowgroup．Allthegroupswereexposedtomicrowavetransmittedbyintercomfortwoweeksexcepttheblankcontrolgroup，8h／d，theradiationdensitywas300uW／cm。，andthefrequencywas409MHz．Thenegativecont

6、rolgroupwasgivenwithdoublesteamedwaterandthetwoextractgroupsweregivenwithcorrespondingextractiveofMorindaofficinalishowfortwoweeks，20g·kg·d～，onceaday．Onedayfollowingthelastdose。thebodyweight，testisandepididymiswereweighted，thentheorganindexwascalculated．Themorphologicchangesoftest

7、iculartissueandepididymistissuewereobservedwithopticalmicroscopeandelectronmicroscope．Results：Nosignificantdifferencesonthebodymassorontheorganindexwerefoundbetweeneverytwogroups．Pathologicalchangeswerefoundinthegroupsexposedtomicrowaveradiation．TherepairedeffectofMorindaofficinal

8、ishowwasfoundinthetwoextractgroup