白血病课件(陈方平).ppt

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1、Leukemia（白血病）陈方平www.themegallery.comLeukemiaTherapyandPrognonisContentsOutlineClassificationClinicalfeaturesDiagnosisAcuteleukemaChronicleukemawww.themegallery.comWhatIsLeukemia?CancerofthewhitebloodcellsAcuteorChronicAffectsabilitytoproducenormalbloodcellsBonemar

2、rowmakesabnormallylargenumberofimmaturewhitebloodcellscalledblastswww.themegallery.comDefinitionAbnormalityofWBCMarrowfailureInfiltrationoftissuesHematopoieticstemcellmalignanciesMalignantproliferationofleukemiccellswww.themegallery.comDevelopmentofLeukemiaintheBl

3、oodstreamStage1-NormalStage2-SymptomsStage3-DiagnosisStage4-WorseningStage5a-AnemiaStage5b-InfectionLegendWhiteCellRedCellPlateletBlastGermSourcesfromLeukemia,byD.NewtonandD.Siegelwww.themegallery.comHistoryMeans“whiteblood”inGreekDiscoveredbyDr.AlfredVelpeauinFra

4、nce,1827NamedbypathologistRudolfVirchowinGermany,1845www.themegallery.comResultsinChina（N/100,000）Morbilityinadults2.01.0ANLLALLCMLCLL1.620.690.360.05Morbilitywww.themegallery.comEtiologyVirusRadiationChemicalsInheritanceOtherkindsofhematopoieticdiseasewww.themega

5、llery.comClassificationofleukemiaAcuteChronicMyeloidoriginLymphoidoriginAcuteMyeloidLeukemia(AML)AcuteLymphoblasticLeukemia(ALL)ChronicMyeloidLeukemia(CML)ChronicLymphocyticLeukemia(CLL)www.themegallery.comHematopoieticStemCellLifespanDecadesYearsMonthsWeeks,DaysR

6、edbloodcellsWhitebloodcellsPlateletswww.themegallery.comLifespanDecadesYearsMonthsWeeks,DaysRedbloodcellsWhitebloodcellsPlateletsHematopoieticStemCellwww.themegallery.comRedbloodcellsWhitebloodcellsPlateletsHematopoieticStemCellwww.themegallery.comRedbloodcellsWhi

7、tebloodcellsPlateletsHematopoieticStemCellwww.themegallery.comAcuteLeukemiaHematopoieticStemCellwww.themegallery.comHematopoieticStemCellChemotherapywww.themegallery.comHematopoieticStemCellRedbloodcellsWhitebloodcellsPlateletsRemissionResidualleukemiastemcellswww

8、.themegallery.comHematopoieticstemcellNeutrophilsEosinophilsBasophilsMonocytesPlateletsRedcellsMyeloidprogenitorLymphoidprogenitorB-lymphocytesT-lymphoc