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1、FeaturesofMycoplasmapneumoniaeandMpneumoniaePneumoniaOrganismSlow-growing,pleomorphic,nonmotilebacteriaLacksaconventionalbacterialcellwall,boundinsteadbyasingle,triple-layeredmembranePneumoniaMpneumoniaeinfectionoccursworldwide,throughouttheyear,withoutsignificantseasonalvariationsChildrenandyoungad
2、ultsaremostofteninfectedTransmissionisfrompersontopersonbydropletinhalationClinicalManifestationofInfectionWithMpneumoniaeMycoplasmapneumoniaeAttachmentHostlungepithelialcellsInterruptscellRNAandproteinsynthesisExtensiveepithelialcellinjuryFeaturesofChlamydiapneumoniaeandCpneumoniaePneumoniaOrganism
3、Obligateintracellular,gram-negativebacillusExistsin2forms,infectiveelementarybodies,andreproductivereticulatebodiesMultiplieswithinmembrane-boundvacuolesineukaryotichostcells,andaredependentonhostforenergy(ATP)andnucleotidebiosynthesisPneumoniaInvolvedinawidespectrumofrespiratorytractinfectionsinbot
4、himmunocompetentandimmunocompromisedhostsElderlypatientsandthosewithcoexistingcardiopulmonarydiseasearemorelikelytohaveseverediseaseOftenpresentaspartofamixedinfectionLifeCycleofChlamydiaSpecies1,21BlanchardTJ,MabeyDC.BJCP.1994;48:201-5.2MandellGL,etal(eds)Principlesandpracticeofinfectiousdiseases4t
5、hedition,1995ChurchillLivingstone.EBEBEBEBEBEBEBEBEBRBRBSusceptiblehostcellAttachmentReceptor-mediatedendocytosisInhibitionoflysosomalfusionReorganization/enlargementofEBtoformRBEB—elementarybodyRB—reticulatebodyaminoacidsenergyfromhostcellReplicationbybinaryfissionCelllysisCpneumoniaeInfectionsCAPP
6、haryngitisSinusitisOtitismediaAcutebronchitisAECBAtherosclerosisAsthmaIncidenceofCpneumoniaeandMpneumoniaeinOutpatientCAPInfectionsMarrieTJ,etal.AmJMed.1996;101:508-15.IncidenceofMpneumoniaeAcuteInfection inChildrenWithLowerRespiratoryTractDiseasesPrincipiN,etal.ClinInfectDis.2001:32:1281-9.Incidenc
7、eofCpneumoniaeAcuteInfectioninChildrenWithLRTDiseasesPrincipiN,etal.ClinInfectDis.2001:32:1281-9.ClinicalResponseinTheseChildrenFollowingAntibioticTherapyPrincipiN,etal.ClinInfectDis.2001:32:1281-9.P<
