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1、Seediscussions,stats,andauthorprofilesforthispublicationat:https://www.researchgate.net/publication/7318111ActivitiesofMicafunginagainst315InvasiveClinicalIsolatesofFluconazole-ResistantCandidaspp.ArticleinJournalofClinicalMicrobiology·February2006ImpactFactor:3.99·DOI:10.1128/JCM.44.2.324-326.2006
2、·Source:PubMedCITATIONSREADS107306authors,including:DanielDiekemaLindaBoykenUniversityofIowaUniversityofIowa324PUBLICATIONS20,748CITATIONS73PUBLICATIONS3,809CITATIONSSEEPROFILESEEPROFILEMichaelPfallerJMILaboratories872PUBLICATIONS56,905CITATIONSSEEPROFILEAllin-textreferencesunderlinedinbluearelinke
3、dtopublicationsonResearchGate,Availablefrom:MichaelPfallerlettingyouaccessandreadthemimmediately.Retrievedon:28June2016JOURNALOFCLINICALMICROBIOLOGY,Feb.2006,p.324326Vol.44,No.20095-1137/06/$08.000doi:10.1128/JCM.44.2.324326.2006Copyright©2006,AmericanSocietyforMicrobiology.AllRightsReserved.Activ
4、itiesofMicafunginagainst315InvasiveClinicalIsolatesofFluconazole-ResistantCandidaspp.11,31111,2S.A.Messer,D.J.Diekema,L.Boyken,S.Tendolkar,R.J.Hollis,andM.A.Pfaller*123DepartmentsofPathology,Epidemiology,andMedicine,RoyJ.andLucilleA.CarverCollegeofMedicine,andCollegeofPublicHealth,UniversityofIowa,
5、IowaCity,Iowa52242Received17October2005/Returnedformodification21November2005/Accepted29November2005Micafunginisanewechinocandinexhibitingbroad-spectrumactivityagainstCandidaspp.TheactivityoftheechinocandinsagainstCandidaspeciesknowntoexpressintrinsicoracquiredresistancetofluconazoleisofinterest.Wede
6、terminedtheMICsofmicafunginandcaspofunginagainst315invasiveclinical(bloodstreamandothersterile-site)isolatesoffluconazole-resistantCandidaspeciesobtainedfromgeographicallydiversemedicalcentersbetween2001and2004.MICsweredeterminedusingbrothmicrodilutionaccordingtotheCLSIreferencemethodM27-A2.RPMI1640
7、wasusedasthetestmedium,andweusedtheMICendpointofprominentgrowthreductionat24h.Amongthe315fluconazole-resistantCandidaisolates,146(46%)wereC.krusei,110(35%)wereC.glabrata,41(13%)wereC.albicans,and18(6%)werele
