【欧洲整形美容技术】

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1、WOUNDHEALINGAdiposeStromalCellsandPlatelet-RichPlasmaTherapiesSynergisticallyIncreaseRevascularizationduringWoundHealingMatthewW.Blanton,M.D.IvanHadad,M.D.BrianH.Johnstone,Ph.D.JuliaA.Mund,B.A.PamelaI.RogersBarryL.Eppley,M.D.,D.M.D.KeithL.March,M.D.,Ph.D.Indianapolis,Ind.Background:Theauthorsex

2、aminedtheefficacyofadiposestemcells,whensuppliedeitheraloneorinplatelet-richfibringels,toimprovewoundhealing.Methods:Aporcinefull-thicknesswoundmodelwasusedtocomparesixtopicaltreatments:platelet-poorplasma;platelet-richplasma;autologousadiposestemcellsplusplatelet-poorplasma;autologousadiposest

3、emcellsplusplatelet-richplasma;allogeneicadiposestemcellscontaininggreenfluorescentproteinplusplatelet-poorplasma;andsaline(control).Oneweekafterisolation,adiposestemcellswereappliedtofull-thicknesswoundsontheparaspinalandthoracicregionsofthreepigs(44woundsperpig;eachtreatmentwasappliedtoeights

4、eparatewounds).Eachwoundwasmonitoredover21daysforclosure,cosmesis,andhistopathology.Results:Therewasnosignificantdifferenceinthereepithelializationrate,buttreatmentscontainingadiposestemcellsdemonstratedincreasedmicrovesseldensities(31.75
5.73vessels/cm2versus7.93
3.61vessels/cm2)comparedwithgr

5、oupswithoutadiposestemcells.Woundcosmesiswasimprovedintheadiposestemcellplusplatelet-richplasmagroupcomparedwithothertreat-mentgroups(p0.05).Vascularendothelialgrowthfactorlevelsdetectedinmatricescontainingadiposestemcellswereapproximately7-foldhighercom-paredwithplatelet-richplasmaorplatelet-

6、poorplasma(p0.05).Localizationoftransgenicgreenfluorescentproteinplusadiposestemcellsindicatedin-corporationnearneovasculature.Conclusions:Innormalhealingwounds,adiposestemcellsappeartoenhancethehealingprocessonlywhenprovidedinafibringelvehiclecontaininganumberofcomplementarywound-healingtroph

7、icfactors.Perivascularadipose美丽热线:0451-82288201地址:哈尔滨市香坊区赣水路12-5号网址：www.sfzxyy.comstemcelllocalizationsuggestsafunctioninenhancingbloodsupplythroughprovidingphysicalandparacrinesupporttonewlyformingvessels.(Plast.Reconstr.Surg.123