《细胞亚群》PPT课件

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1、T细胞亚群ClassesoflymphocytesT细胞亚群T细胞活化分子机制T细胞免疫应答及其效应自身免疫和超敏反应TcellsubsetsTcellsandTcellsCD4+TcellsandCD8+TNaïveTcells（初始T细胞）EffectorTcells（效应T细胞）MemoryTcells（记忆T细胞）Thelper(Th)辅助性CD4+T细胞CytotoxicTcells(CTLs)细胞毒性CD8+T细胞RegulatoryTcells(Tregs)调节性CD4+T细胞TCellsubsetsClassFunc

2、tionsAntigenreceptorandspecificitySelectedmarkersPercentoftotallymphocytes(human)αβTlymphocytesBloodLymphnodeSpleenCD4+helperTlymphocytesBcelldifferentiation(humoralimmunity)Macrophageactivation(cell-mediatedimmunity)αβheterodimersDiversespecificitiesforpeptide-classIIMHC

3、complexesCD3+,CD4+,CD8-50-60*50-6050-60CD8+cytotoxicTlymphocytesKillingofcellinfectedwithmicrobes,killingoftumorcellsαβheterodimersDiversespecificitiesforpeptide-classIMHCcomplexesCD3+,CD4-,CD8+20-2515-2010-15RegulatoryTcellsSuppressfunctionofotherTcells(regulationofimmune

4、responses,maintenanceofself-tolerance)αβheterodimersCD3+,CD4+,CD25+(Mostcommon,butotherphenotypesaswell)Rare1010γδTlymphocytesHelperandcytotoxicfunctions(innateimmunity)γδheterodimersLimitedspecificitiesforpeptideandnonpeptideantigensCD3+,CD4,andCD8variableTcellsexpressa

5、limitednumberofTCRsabundantinepithelialtissuesofcertainspecies:inthesmallbowelmucosaandintheskinofmouse.Intheskin,knownasadendriticepidermalTcell(DETC)donotrecognizeMHC-associatedpeptideantigensandarenotMHCrestricted.maybindtoconservedligandswhoseexpressionistriggeredbycel

6、linjuryorstress,suchasmicrobialheatshockproteins.mayrepresentanimportantbridgebetweeninnateandadaptiveimmunity,functioningaslymphocytesthatenhancethefirstlineofdefenseagainstarangeofpathogens.Jensen,K.D.etal.ThymicselectiondeterminesTcelleffectorfate:antigen-naivecellsma

7、keinterleukin-17andantigen-experiencedcellsmakeinterferonImmunity29,90–100(2008).EpithelialTcellandPeripheralTcellCD27-IL-17+TcellsandCD27+IFN-+TcellsSubsetsofTcellsDevelopmentalprogrammingofTcellsubsets.CuaDJ,etal.NaturereviewImmunology,2010MartinBetal.IL-17

8、-ProducingTcellsSelectivelyExpandinResponsetoPathogenProductsandEnvironmentalSignals.Im