欢迎来到天天文库
浏览记录
ID:38565679
大小:257.53 KB
页数:123页
时间:2019-06-15
《ign骨质疏松的管理与脆性骨折的预防》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、Managementofosteoporosisandthepreventionoffragilityfractures骨质疏松的管理与脆性骨折的预防ScottishIntercollegiateGuidelinesNetwork苏格兰校际指南网LEVELSOFEVIDENCE1++Highqualitymeta-analyses,systematicreviewsofRCTs,orRCTswithaverylowriskofbias1+Wellconductedmeta-analyses,systematicreviews,orRCTswithalowriskofbias1-Me
2、ta-analyses,systematicreviews,orRCTswithahighriskofbias2++HighqualitysystematicreviewsofcasecontrolorcohortstudiesHighqualitycasecontrolorcohortstudieswithaverylowriskofconfoundingorbiasandahighprobabilitythattherelationshipiscausal2+Wellconductedcasecontrolorcohortstudieswithalowriskofconfound
3、ingorbiasandamoderateprobabilitythattherelationshipiscausal2-Casecontrolorcohortstudieswithahighriskofconfoundingorbiasandasignificantriskthattherelationshipisnotcausal3Non-analyticstudies,egcasereports,caseseries4ExpertopinionTheneedforaguidelineIn2012,fracturesoccurredin19.8outof1,000womenand
4、8.4outof1,000menovertheageof50inScotland.Themajorityoffracturesoccurinpeopleovertheageof65andalargeproportionofthesepatientshaveosteoporosis.Fracturesareanimportantcauseofmorbidity,andpatientswhosufferhipfractures髋部骨折andvertebralfractures椎体骨折haveadecreasedlifeexpectancycomparedwithpopulation-ba
5、sedcontrols.2Keyrecommendations2.1riskfactorsPeoplewithahistoryoffragilityfracturesovertheageof50shouldbeofferedDXAscanningtoevaluatetheneedforantiosteoporosistherapy.2Keyrecommendations2.2quantifyingtheriskoffractureFracture-riskassessmentshouldbecarriedout,preferablyusingQFracture,priortoDXAi
6、npatientswithclinicalriskfactorsforosteoporosisandinwhomantiosteoporosistreatmentisbeingconsidered.MeasurementofbonemineraldensitybyDXAatthespineandhipshouldbecarriedoutfollowingfracture-riskassessmentinpatientsinwhomantiosteoporosistreatmentisbeingconsidered.2Keyrecommendations2.3managementofo
7、steoporosisinpostmenopausalwomenRepeatBMDmeasurementsbyDXAafteranintervalofthreeyearsmaybeconsideredtoassessresponsetotreatmentinpostmenopausalwomenonalendronicacid阿仑膦酸,ibandronicacid伊班膦酸,zolendronicacid唑来磷酸ordenosumab狄诺塞麦therapy.
此文档下载收益归作者所有