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ID:34096130
大小:9.63 MB
页数:54页
时间:2019-03-03
《安胃疡胶囊治疗慢性浅表性胃炎药效学试验与机制分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、硕士学位论文3.3安胃疡胶囊抗炎作用小鼠腹腔毛细管通透性实验结果表明,与模型对照组比较,安胃疡胶囊高、中和低剂量组腹腔洗涤液oD值降低,中、低剂量组具有显著性差异;大鼠角叉菜胶致炎后,在30min、60min时间点,安胃疡胶囊高、中剂量组显著抑制大鼠足趾肿胀程度,中剂量组抗炎作用时间延伸至90min。3.4安胃胶囊镇痛作用在扭体实验中,安胃疡胶囊可延长小鼠首次扭体的潜伏期,同时降低20min内扭体次数,与模型对照组比较,安胃疡胶囊高、中和低剂量组小鼠的潜伏期均显著延长,扭体次数均显著降低;大鼠甩尾实验结果表明,与模型对照组比较,安胃疡胶囊高剂量
2、组在给药后30min有显著性镇痛作用,中、低剂量组在给药后60min有显著性镇痛作用。4、研究结论4.1安胃疡胶囊对慢性浅表性胃炎(CSG)的药效学作用主要表现在以下方面:4.1.1抑制CSG胃黏膜炎症,减少炎症对胃黏膜的损伤。4.1.2恢复胃黏膜屏障,对损伤的胃黏膜具有保护和修复作用。4.1.3改善胃肠激素的分泌,减少攻击因子分泌。4.2安胃疡治疗慢性浅表性胃炎相关药理机制安胃疡胶囊对慢性浅表胃炎的药效学作用与抑制体内的促炎细胞因子IL一1B、IL一8水平,提高PGE:水平,上调T淋巴细胞CD4+/CD8+比例,改善机体免疫功能等机制相关。4
3、.3抗炎、镇痛作用抗炎实验结果表明,安胃疡胶囊对小鼠腹腔炎症及大鼠足趾炎症具有显著的抑制作用。小鼠镇痛实验证明,安胃疡胶囊具有显著的镇痛作用,镇痛作用V摘要起效时间与药物剂量相关。关键词:安胃疡胶囊慢性浅表性胃炎T淋巴细胞亚群炎症细胞因子VI硕士学位论文StudyofPharmacodynanicsandMechanismofAnweiyangcapsuleonchronicsuperficialgastritis(cs6)Name:LinXiao.chunSupervisor:TongLi1.0bjectivesandsignificance
4、C11ronicsuperficialg砌tis(CSG),themostcommonc11ronicgastritisinclinic,isadiseaseingastricmucosalcausedbymanyreasons.Itismainlymarkedbycllronicinflammatorycellsinfiltrationsuchasplasmacellsinthemucouslayerandlymphocyte,noatrophicgastricmucosalchangesassociated.Accordingtoepide
5、miologicalinvestigation,morbidityofc11ronicgastritisWashighestamongstomachdiseaseswim51.7%~85.45%cllronicsuperficialgastritisandincreaseswiththegrowthofagewhilenoremedialmethodofespeciallygoodeffectexists.Mostofthescholarsathomeandabroadrecognized“CSG-CAG-ventriculiphthisis-
6、ntestinalmetaplasia-dysplasia·gastriccancer’’asthedevelopingmodelofCSGIn1978,c11ronicatrophicgastritisWaslistedasprecancerousconditionofgastriccarcinomabyWHO,andifaccompaniedbyIMormoderate,severeatypicalhyperplasia,itwillberecognizedaspremalignantlesion.Therefore,effectivetr
7、eatmentoncllronicsuperficialgastritisisofgreatsignificanceinthepreventionofdigestivetractcancer.WithGeneralHuangTonglicorice(1icoriceextract)asmaincontent,AnweiyangCapsuleisusedtotreatgastricandduodenalulcerandmaintenancetreatment,tonifyingmiddle-JiaoandQi,detoxifingandpromo
8、tinggranulation.Anweiyangisalsousedforthetreatmentofc11ronicgastritisclinic
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