重组人骨形成蛋白2复合胶原基纳米骨修复下颌骨缺损的实验分析

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1、ABSTRACTexamination，histologicalsectionsbylightmicroscopyandscanningelectronmicroscopy．ScoretheresultsbasedoncomprehensiveevaluationofrhBMP．2／nHACartificialbonerepairmaterialofthemandibulardefectsrepaircapacityandosteogeniceffect．3．Results1．Generalobservation：Duringtheentireexperimentinal

2、lanimalsenteredthefinalanalysis，noloss．Inallexperimentalperiod，experimentalanimalsgrewwell，weightincreasedsteadily．Woundhealedwellwithoutimplantextrusion，noforeignbody,theimmuneresponseandotherrowsignsofinfection，allanimalsdidnotoccRrsecondarytofracture．2．Generalobservationofspecimens：ind

3、ifferentperiodsaftersurgery,grossanatomyhavenotbeenoccurredsofttissuegraftdegenerationornecrosis．Connectivetissuefibersattachedtothesurfaceofplants，abundantangiogenesis．Withtheobservationperiod,materialsappearanceandtextureweregraduallyapproachingtothemandibularbone，materialsfirmlyconnect

4、edthemandibular．3．X-rayobservations：At5mweek，experimentalsidedefectcanbeseenpartialcloudinessdefectdensityshadow；ContrastsidedefectCanbeseenlow-densityimplants，bonedefectsareclearlyvisibleboundaries．At10mweek,theexperimentalsidebonedefectareacanbeseenprojectivepatchyresistance，bonedefectb

5、oundariesarenotclear,thebone—beddepartmentdensityincreasedslightly,showingdenseshadowcloudinessandnewboneformation，bonegraftisstillvisible；Contrastsidedefectbonedefectgapclear,nearlynoobviousbone-beddepartmenttorepairbonecallusformation，boneclearboundaries．At20mweek,experimentalsidedefect

6、Wasconnectedfuzzygapbonedefect,inordertostopthecontinuityofhigh-densityprojection，blurredbone；ContrastsideandtherelativelylowbonedensityunevendensityWaspatchyshadow,transplantationofboneandbonedefectsCanbeseenfuzzyspace．Lane·-SandhuX··rayscoreresults：Inadditionto5weeksafteroperationduetom

7、aterialsnotintheX—rayfilmautoradiographyledtonoresults，after10weeksand博士学位论文20weekstheexperimentalgroupandcontrolgroupinthenewboneformation,boneconnectivityandboneremodelingweresignificantdifferencesexist(tl=3．162，Pl=0．025；t2---4．568，P2=O．006)，experimentalgroupthant