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ID:33103455
大小:5.57 MB
页数:56页
时间:2019-02-20
《消炎止痛膏(东乐膏)外治类风湿关节炎关节疼痛的临床研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中国中医科学院硕士学位论文消炎止痛膏(东乐膏)外治类风湿关节炎关节疼痛的临床研究姓名:刘乐申请学位级别:硕士专业:中医内科学指导教师:寇秋爱20120528消炎止痛膏(东乐膏)外治类风湿关节炎关节疼痛的临床研究中文摘要1目的:通过临床试验研究,验证在控制活动期类风湿关节炎(RheumatoidArthritis,RA)关节疼痛方面,内科治疗加用具有“清热解毒、行气活血、消肿止痛”作用的消炎止痛膏,对缓解活动期RA关节疼痛较单纯内科治疗具有良好的效果,为减轻活动期RA患者的疼痛,提供一条新的治疗途径。2方法:本研究的临床设计遵循随机、对照、重复
2、的原则,并采用双盲的方法。纳入“热毒蕴结、气滞血瘀”型活动期RA关节疼痛患者72例,按l:1比例随机分为两组,即消炎止痛膏组和安慰剂组各36例,消炎止痛膏组在符合基础用药的规定上加用消炎止痛膏,安慰剂组在符合基础用药的规定上加用消炎止痛膏模拟剂(安慰剂)。对所有受试者的主要疗效指标(视觉模拟评分法(visualanaloguescaleVAS疼痛评分)、关节局部疼痛评分)、次要疗效指标(关节症状总积分、临床疗效评分、局部关节肿胀评分、局部关节发热评分、局部关节发红评分、屈伸不利评分、晨僵评分、患侧握力、15米步行时间、血沉(Erythrocy
3、teSedimentationRateESR)、C反应蛋白(C—reactiveProteinCRP)等)进行评价,分析并评估消炎止痛膏组与安慰剂组治疗前后的临床意义。3结果:3.1主要疗效指标VAS疼痛评分、关节局部疼痛评分方面,消炎止痛膏组优于安慰剂组(P均<0.05)。3.2次要疗效指标关节症状总积分、临床疗效评分方面,消炎止痛膏组明显优于安慰剂组(P均<0.01)。局部肿胀评分方面,与安慰剂组比较,无显著性差异:但消炎止痛膏组与安慰剂组较疗前均有显著性差异(P均4、组与安慰剂组较疗前均有显著性差异(P5、义(P6、atinthecontrolofactiverheumatoidarthritis(RA)jointpain,medicaltreatmentplustheroleof“heating-clearinganddetoxifying,promotingcirculationofqiandblood,releasingswellinganalgesia’’anti—inflammatoryanalgesiccreamtoalleviatejointpainthanasimplemedicaltreatmenthasagoodeffect,tore7、ducetheactivityofthepainofRApatients,toprovideanewtherapeuticapproach.2Methods:Theclinicaldesignfollowswiththeprincipleofrandomized,controlled,repeatandadopteddouble—blindmethods.Includedinthe“ToxicHeatAccumulationandQistagnationbloodstasis”,72casesofpatientswithactiveRApai8、nwererandomlydividedintotwogroups(1:1),36casesofanti-inflammatoryanalgesiccreamgro
4、组与安慰剂组较疗前均有显著性差异(P5、义(P6、atinthecontrolofactiverheumatoidarthritis(RA)jointpain,medicaltreatmentplustheroleof“heating-clearinganddetoxifying,promotingcirculationofqiandblood,releasingswellinganalgesia’’anti—inflammatoryanalgesiccreamtoalleviatejointpainthanasimplemedicaltreatmenthasagoodeffect,tore7、ducetheactivityofthepainofRApatients,toprovideanewtherapeuticapproach.2Methods:Theclinicaldesignfollowswiththeprincipleofrandomized,controlled,repeatandadopteddouble—blindmethods.Includedinthe“ToxicHeatAccumulationandQistagnationbloodstasis”,72casesofpatientswithactiveRApai8、nwererandomlydividedintotwogroups(1:1),36casesofanti-inflammatoryanalgesiccreamgro
5、义(P6、atinthecontrolofactiverheumatoidarthritis(RA)jointpain,medicaltreatmentplustheroleof“heating-clearinganddetoxifying,promotingcirculationofqiandblood,releasingswellinganalgesia’’anti—inflammatoryanalgesiccreamtoalleviatejointpainthanasimplemedicaltreatmenthasagoodeffect,tore7、ducetheactivityofthepainofRApatients,toprovideanewtherapeuticapproach.2Methods:Theclinicaldesignfollowswiththeprincipleofrandomized,controlled,repeatandadopteddouble—blindmethods.Includedinthe“ToxicHeatAccumulationandQistagnationbloodstasis”,72casesofpatientswithactiveRApai8、nwererandomlydividedintotwogroups(1:1),36casesofanti-inflammatoryanalgesiccreamgro
6、atinthecontrolofactiverheumatoidarthritis(RA)jointpain,medicaltreatmentplustheroleof“heating-clearinganddetoxifying,promotingcirculationofqiandblood,releasingswellinganalgesia’’anti—inflammatoryanalgesiccreamtoalleviatejointpainthanasimplemedicaltreatmenthasagoodeffect,tore
7、ducetheactivityofthepainofRApatients,toprovideanewtherapeuticapproach.2Methods:Theclinicaldesignfollowswiththeprincipleofrandomized,controlled,repeatandadopteddouble—blindmethods.Includedinthe“ToxicHeatAccumulationandQistagnationbloodstasis”,72casesofpatientswithactiveRApai
8、nwererandomlydividedintotwogroups(1:1),36casesofanti-inflammatoryanalgesiccreamgro
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