胸腺组织辐射损伤效应和机理的分析

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1、硕+学位论文：鹏踩组织辐射损伤效成承1机理的研究DNAinjuryandrepaiLapoptosjs，ionchannelandtransportprotcin，metabolism，proteintranslationandsynthesization，development，celldifferentiation，andcytoskeleton．①T11eanalysisaboutthegenes『elatedtocellcycleindicatedthat，afterirradiaIionsomethymocytessuffere

2、dcellcydearrest，whileothefscontinuedthepathwaysoftheircellcircles．②TheanalysisaboutthegenesrcJatedtosi舯altmnsductionpathwaysindicatedthat，somepathwayscouldinhibittheproliferationanddifferentiationofthymiclymphocytes，boweVer'othefpathwayscouldprotectmemfmmdeath．③Theanalysi

3、saboutthegenesrelatedtoimmunityandstressindicatedthat，onthefirstdayandthesixthdayafterradiation，seVerejnflammationandconcurrentlypossibleimmunedeletionoccurredinthethymus．(DOnlhefirstdayandthesixthdayafterradiation，proapoptoticgenesandanti-apoptosisoneswereinacompetition，

4、thalisimport卸tinregulatingapoptosis．⑤Afterradjation，cclIscouldinhibitprolifcrationanddevelopmentthroughdownregulatingthetranscriptionrelatedgenes．5．Y—irradiatjoninducedgeneshavedifferentroIesindi骶rentphases．①T11efi嘣dayafIerradiationisintheacutereacti呻Phase．ononehand，celJs

5、failingtorcpairthemselvescouldbedeletedthroughapoptosis．ontheotherhand，someceJlscouldsurviVethroughactivatinganti—radiationpathways．②onthesixIhdayafccrradiation，auto谢nefadDfScouldSfimHlatethepro甄ferationofthesurviVedcellsinthethymus．Andtheinflammationfactorsalsoplayedanim

6、ponantr01e．③()llthe14dayanerradiation，reactionactivatedautocrinefatorscouldonlyrclievetheda珥agctemporafily，andsomereco玎s俄ut主onfe】atedgeneslookpaninlhethymusrecoVery．④onlhe28dayafterfadiation，thesl『lldureandfunctio耵oflhymusbegantofecoveLitwassupposedthatitmainlymightbethe丁

7、esultsfromthepro】ifemtionofthenewlymi争atedpfogcnitorcellsfmmbonemar舰Keywords：radiaton，thym璐，gene既p腓ssionprofile，g吼echip7碗士学仃论文：胸腺组织辐射_}5{伤效应和机理的研究胸腺组织辐射损伤效应和机理的研究口Ⅱ舌放射免疫损伤及其引发的免疫功能障碍不仅是战时核辐射、平时恶性肿瘤放疗和放射’降核事故患者最常见的重要病症之一，而且至今仍是临床上厦待解决的难题之一。研究辐射对免疫系统的损伤效应、机理和规律，是攻克急性放射病时感染并

8、发症、提高现代放射病救治水平的重要内容之‘。胸腺是T细胞分化成熟并接受阳性和阴性选择的巾枢免疫器官，近年来的研究发现【”，胸腺在成年期继续发挥作用。胸腺功能的重建，是免疫功能重建中重要的一步，