annexina7在喉鳞状细胞癌的表达(5636)

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1、ExpressionofAnnexinA7inlaryngealsquamouscellCarClnomaMasterdegreecandidate：XuSongSupervisor：ProfessorZhaiLijieMajor：OtorhinolaryngologyAbstractobjeetive：TostudythattheexpressionofAnnexinA7inlaryngealsquamouscellcarcinomaO。scc)isdifferentfromthatinadjacentnormallaryngealmucosaandmakeitcer

2、tainthatAnnexinA7mayplayanimportantroleintheoncogenesisandprogressionofLSCCasatumorsuppressorgeneandprovideakindofclinicaltargetforobservingandassessingthemalignantpotentialoflaryngealmucosa．Methods：TheexperimentdetectstheproteinexpressionofAnnexinA7bYimmunohistochemistry(MaxVisionTM)in3

3、1casesofLSCCand32casesofadjacentnormallaryngealmucosatissuesandanalyzetherelationshipbetweentheexpressionofAnnexinA7andage，gender,anatomicaldistrict，pathologicalgradeorclinicalstageofthelaryngealcancerpatients．Results：1AnnexinA7proteinisabundantinthenormallaryngealmucosaandisfoundlocaliz

4、edinthecellmembranebyimmunohistochemistry．Itismanifestedabrowngranularorlinenetworkdistribution．2neexpressionofAnnexinA7Canbedividedintofourgrades．Theyarenegative，weaklypositive，positiveandstronglypositiverespectively．Inthe31c觞esofLSCC，Thereare23casesnegative，5Oflk∞Sweaklypositive,1c觞epo

5、sitiveand2CflSesstronglypositive．However,inthe32c嬲esofadjacentnormallaryngealmucosatissues，therealelcasenegative，2c嬲weaklypositive，9casespositiveand20c勰esstronglypositive．Thereismuchdifferencebetweenthetwogroupswhichistestedstatisticallysignificantbymeansofnonparametrictests．11heexpressi

6、onofAnnexinA7inLSCCismuchlowerthanthatintheadjacentnormallaryngealmucosa．3A儿the31c嬲铭ofLSCCpatientsgallbedividedintotwogroupsaccordingtotheanatomicaldistrict,pathologicalgradeorclinicalstage．TheexpressionofAnnexinA7intwogroupsistestedbym锄sofnonparametrictestsanditisfoundthatthereisnosigni

7、ficantdifference．Bythesamemeans，therelationshipsamongtheexpressionof2AnnexinA7andtheage，gender，anatomicaldistrict，pathologicalgradeorclinicalstageofthelaryngealcancerpatientsaretestedtobenosignificantdifference．Conclusion：1TheA7proteiniswidespreadincells．Itislocalizedinth