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1、ABSTRACTBoneHistomorphometricStudyofEffectsofExercisesonWeightedandNonweightBearingBoneMassoftheOrchidectomizedRatsObjectiveThispaperdiscussedtheeffectandmechanismofdifferentintensitytreadmillexerciseonweightedandnonweightbearingbonemassoftheorchidectomizedRats.MethodsFortymaleSpra
2、gueDawlyratsagedat12weeksweredividedintofollowinggroups:SHAM,ORX,threegroupsofindividualexerciseofdifferentintensity:ORX+EX1,ORX+EX2andORX+EX3.Afterrunningfor10weeks,wekillthemandchooseproximaltibiametaphysis(PTM)andthe4thlumbarvertebralbody(L4)tomakebonesliceswithoutdecalcificatio
3、n,meanwhile,todeterminatediversebonemassindexsandbonearchitectureindexsandbonemetabolismofbonemorphologicalmetrologyandmakeANOVA.Results(1)TheindexsofORXtocompareSHAMshows:bonemassdowns(P<0.05),bonearchitecturetodestroy(P<0.05),ossificationtoweaken(P<0.05),osteoclasttoincrease(P<0.
4、05).(2)TheindexsofORX+EX1andORX+EX2tocompareORXshows:bonemasstoincrease(P<0.05),bonearchitecturetoimprove(P<0.05),ossificationtoincrease(P<0.05),osteoclasttoweaken(P<0.05).(3)TheindexsofORX+EX2tocompareORX+EX1shows:bonemasstoincrease(P<0.05),bonearchitecturetoimprove(P<0.05),ossifi
5、cationtoincrease(P<0.05).(4)TheindexsofORX+EX3tocompareORXshow:bonemassandbonearchitectureisnotdifference(P>0.05),butossificationandosteoclasttoincrease(P<0.05),bonemetabolismtoincrease(P<0.05);theindexsofORX+EX3tocompareORX+EX2show:bonemassdowns(P<0.05),bonearchitecturetodestroy(P
6、<0.05),osteoclasttoincrease(P<0.05).(5)ThebonemassincrementofPTMofORX+EX2ismorethanL4.,Conclusion1.theorchidectomizedRatswilllosebonemassandbonesarchitecture.2.II万方数据,pertinencerunningexercisewillincreasebonemassandbonesarchitecture.3.running,excessexercisewillnotmaintainbonemassan
7、dbonesarchitecture.4.Afterpertinencerunningexercisethebonemassincrementofweight-bearingboneismorethannonweight-bearingbone.,Subjectwordsrat,orchidectomized,runexercises,bonemass,bonesarchitecture,weight-bearingbone,nonweight-bearingbone,histomorphometryIII万方数据一、前言1885年Pommer和Bauer首
8、先提出骨质疏松一词,意为骨质减少性疾病。1941年A