土霉素的生产工艺.doc

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1、天津渤海职业技术学院2012届毕业生毕业论文土霉素的生产工艺目的：土霉素生产工艺的概述。摘要：土霉素提取工艺是通过黄血盐-硫酸锌作净化剂协同去除蛋白质等高分子杂质，然后用122-2树脂脱色进一步净化土霉素滤液，最后调pH至4.8左右结晶得到土霉素碱产品。关键词：生产工艺；土霉素；黄血盐-硫酸锌28天津渤海职业技术学院2012届毕业生毕业论文目录1文献综述·················································41.1霉素简介·····················································51.1.1名称与

2、化学结构式············································51.1.2性状与理化质················································61.2土霉素生产菌种···············································62土霉素生产工艺·······················72.128天津渤海职业技术学院2012届毕业生毕业论文土霉素的生产工艺流程概述····································72.2发酵工艺流程············

3、····································72.2.1斜面孢子制备················································72.2.2一级种子罐发酵··············································72.2.3二级种子罐发酵··············································72.2.4三级发酵罐发酵··············································82.3酸化过滤工艺流程············

4、································92.3.1酸化28天津渤海职业技术学院2012届毕业生毕业论文························································92.3.1.2发酵液的纯化···············································102.3.2过滤·······················································102.4脱色结晶工艺流程·······································

5、·····112.4.1脱色························································112.4.2结晶························································112.5.1离心·······················································132.5.2干燥·······················································132.5.2.1湿成品干燥记录··················

6、········28天津渤海职业技术学院2012届毕业生毕业论文···················133土霉素生产的废水处理····················133.2该生产废水处理方案··········································143.2.1高压脉冲电凝水处理技术进行预处理····························143.2.2复合絮凝(气浮)技术降低抗生素残余效价························153.2.3组合兼氧技术进行水解酸化····································1

7、53.2.4生物活性炭滤池进行深度处理··································163.3生产废水处理设备及参数······································174土霉素的微生物限度检验方法···························184.128天津渤海职业技术学院2012届毕业生毕业论文材料·····································