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1、关于的李辽源论著目录关于的李辽源论著目录导读:expressionbyimmunohistochemistryon198prostatebiopsiesediate-risklocalized(局限)prostatecancer.Themedianfolloonths(range,6-60)forallpatients.Ourresultsshoa3A(OR:0.19,P<0.001),Sema3B(OR:0.38,P=0.003),Sema3E(OR:0.39,P=0Liao-YuanLi2012广东科技进步一等奖(第七)前列腺癌的分子诊断与微创治疗1
2、、Thepredictivevalueofsemaphorins3expressioninbiopsiesforbiochemicalrecurrence(复发)ofpatientsediate-riskprostatecancer2014SCIAbstractTheclass-3semaphorins(Sema3A-F,Sema3s)areinitiallyidentifiedtoplayanimportantroleinaxonal(轴突)guidanceandcellmigration.Ourpreviousstudiesshoa3sarealsoinv
3、olvedinthelymphnodemetastasisofprostatecancer,andarelikelytomodulatethebehaviorofprostatecanceroralorananti-tumoraleffect,dependingontheirsubtypes.Hoa3sexpressioninpreoperativebiopsy(活检)samplesforthepredictionofbiochemicalrecurrence(BCR)afterradical(根治)prostatectomy.Inthisstudy,a3se
4、xpressionbyimmunohistochemistryon198prostatebiopsiesediate-risklocalized(局限)prostatecancer.Themedianfolloonths(range,6-60)forallpatients.Ourresultsshoa3A(OR:0.19,P<0.001),Sema3B(OR:0.38,P=0.003),Sema3E(OR:0.39,P=0.007),andSema3C(OR:2.31,P=0.014)staining(着色)wereindependentpredic34
5、5678关于的李辽源论著目录导读:inpredictingBCRuponsurvivalanalysis(P=0.001,P=0.003,P=0.029,P=0.037,respectively,Log-ranktest(对数秩检验)).OurfindingssuggestedthatSema3A,3B,3C,and3Eimmunostaininginprostatebiopsies,assupplementstoclinicopathologicalparameters(参数),couldbeusedforpredictingBCRintorsofBCRon
6、multivariableanalysis.Sema3A,3B,3Cand3EexpressiondemonstratedpotentialvaluesinpredictingBCRuponsurvivalanalysis(P=0.001,P=0.003,P=0.029,P=0.037,respectively,Log-ranktest(对数秩检验)).OurfindingssuggestedthatSema3A,3B,3C,and3Eimmunostaininginprostatebiopsies,assupplementstoclinicopatholog
7、icalparameters(参数),couldbeusedforpredictingBCRinloediate-riskprostatecancerpatientsafterradicalprostatectomy.Specially,concurrentSema3C-positiveandSema3A-negative,3B-negative,3E-negativestainingisassociated(伴随)aphorins,slits,rins和ehprins。其中semaphorins是一个至少包含20个成员的大家族,它的成员都是分泌型或与膜结合的
8、蛋白Semaphorin的受体主要包括