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1、山泽参黄汤治疗非酒精性脂肪性肝炎的疗效观薛江洲吴红梅(江苏省丹阳市中医院江苏丹阳212300)【摘要】目的研宄山泽参黄汤治疗非酒精性脂肪性肝炎(NASH)的疗效及安全性。方法63例NASH患者随机分为对照组和治疗组，对照组采用复方益肝灵治疗，每日3次，每次4片。治疗组给予山泽参黄汤口服，每日1剂，每剂煎服2次，连用3个月。治疗前及治疗结束后分别测量体重指数、腰/臀比，检测空腹血糖、血脂、胰岛素、肝功能，计算胰岛素抵抗指数｛IRI｝、肝脏B超积分。结果治疗3个月以后，两组病人血糖、血脂、肝功能和B超积分均有
2、不同程度的改善，但治疗组在降低TG、LDL-C、FBS、IRI和改善肝功能方面显著优于对照组.两组总有效率分别为84.4%和61.4°%,治疗组显著高于对照组(P<0.05)。结论山泽参黄汤治疗NASH安全有效，能减轻脂肪肝，改善肝功能。【关键词】非酒精性脂肪性肝炎山泽参黄汤体重指数胰岛素抵抗指数肝功能腰/臀比【中图分类号】R243【文献标识码】A【文章编号】2095-1752(2012)24-0141-03EvaluationoftherapeuticefficacyofShan-Ze-Shen-Hua
3、ngdecoctionforpatientswithnon-alcoholicsteatohepatitisXuJiang-Zhou,WuHong-MeiDanyangTCMPeopledHospital[Abstract]ObjectiveToevaluatethetherapeuticeffectofShan-Ze-Shen-Huangdecoctionforpatientswithnon-aleoholiesteatohepatitis(NASH).Methods63caseswithNASHwer
4、erandomlydividedintotwogroups.GroupAincluding32patientsweretreatedwithShan-Ze-Shen-Huangdecoction，amixturecomposedofDioscoreaoppositaThunb,AlismatisRhizoma,DanShenandCoptischinensisFranch,for3months.GroupB(controlgroup)treatedwithFufangYiganlingTablet4#ti
5、d,forthreemonths.Beforeandtheendoftreatment,thedataofclinicalsymptomsandphysicalsigns，Bodymassindex(BMI)，Waist-hipratio(W/HR)wererecorded,andfastingbloodglucose(FBS)，insulin(FINS),lipids，liverfunctiontestsandliverultrasonographicimagescorewereseriallymeas
6、ured.ResultsAscomparedwithbasalvalues，bothgroupsafterthree-monthtreatmentshowedanimprovementtosomeextentinFBS，lipids,insulinresistanceindex(IRI),liverfunctionandhepaticultrasonographicscore,butGroupAwassignificantlysuperiortogroupBinreductionofTG,LDL-C,FB
7、S,andinamelioratingliverfunction.ThetotaleffectiverateingroupA(84.4%)wasmuchhigherthaninincontrolgroup(61.4%),P<0.05.ConclusionShan-Ze-Shen-HuangdecoctionwasaneffectiveandsafemedicationintreatingNASHpatients,aboveallinlighteningfattyliverandimprovingliver
8、function.【Keywords】non-alcoholicsteatohepatitisShan-Ze-Shen-HuangdecoctionBodymassindexinsulinresistanceindexliverfunctionWaist-hipratio非洒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗(1「)、遗传易感性相关的代谢应激性肝损伤，轻者仅为单纯性脂肪肝，呈可逆性；若不给予适当处理，则可发展为非酒
