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1、fromWuandMorris,Curr.Opin.Genet.Dev.9,237(1999)ExamplesofHomology-dependentGeneSilencingTGS–PairingoftightlylinkedhomologouslociinducesmethylationPTGS–Transcript-specificdegradationSAS–SpreadofPTGSRIP–InductionofC-TtransitionsRNAifromWuandMorris,Curr.Opin.Ge
2、net.Dev.9,237(1999)ModelsforTransvectionTransvectionisanalterationofgenefunctionbyhomologouspairingtransactionofanelementonapairedhomologPropagationofchromatinstructuretoapairedhomologPairing-sensitivesilencingthatactsatthelevelofchromatinRNAtriggerssilencin
3、gatpairedhomologsPairingofdissimilarhomologscausesatopologicalchangefromMcManusandSharp,NatureRev.Genet.3,737(2002)ResponseofMammalianCellstoLongdsRNALongdsRNAinducesinterferonresponseinvertebratesPKRphosphorylateseIF2atoinhibittranslation2’-5-oligoadenylate
4、synthaseisinduced,whichactivatesRNaseLandleadstononspecificmRNAdegradationsiRNAdoesnotinvoketheinterferonresponseThelin-14MutanthasanAlteredPatternofCellDivisionThePNDBneuroblastisgeneratedprematurelyTheLIN-14proteinpreventsL2-typecelldivisionsfromLodishetal
5、.,MolecularCellBiology,6thed.Fig21-6fromLodishetal.,MolecularCellBiology,6thed.Fig21-6TheLIN-14proteinpreventsL2-typecelldivisionsDuringL2,lin-4miRNApreventstranslationoflin-14mRNAIntheadult,let-7inhibitslin-14andlin-41translationAbsenceofLIN-41permitslin-29
6、translationandgenerationofadultcelllineagesmiRNAsRegulateDevelopmentinC.elegansfromLiandHannon,NatureRev.Genet.5,522(2004)lin-4InhibitsTranslationoflin-14mRNAMutationsinlin-4disruptregulationoflarvaldevelopmentinC.eleganslin-4antagonizeslin-14functionlin-4en
7、codesa22nt-longmicroRNAthatispartiallycomplementarytositesinthe3’UTRoflin-14mRNAAnnealingoflin-4tolin-14mRNAinhibitstranslationfromLiandHannon,NatureRev.Genet.5,522(2004)BiogenesisofmiRNAsandsiRNAsmiRNAsaregenomicallyencodedsiRNAsareproducedexogenouslyorfrom
8、bidirectionallytranscribedRNAsmiRNAshaveimperfectcomplementaritytotheirtargetmRNAandinhibittranslationsiRNAsformperfectduplexwiththeirtargetmRNAandtriggermRNAdegradationDroshaprocessespri-miRNAt
