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1、大连工业大学2010届本科毕业生论文摘要淀粉微球作为一种理想的药物载体,其合成和功能化改性成为人们关注的热点。采用新的制备方法获得具有良好稳定性的淀粉微球,使其载药、释药性能得以改善,对于更深入开展淀粉微球应用性能研究,提高其在现代药物制剂技术中的实际应用价值,拓展其应用领域都有着重要的意义。本文以可溶性淀粉为原料,环氧氯丙烷为交联剂,同时选用Span60作为乳化剂,大豆油为油相,采用反相乳液法合成淀粉微球。研究过程中,重点考虑油水相体积比、乳化剂用量、交联剂种类和用量、淀粉浓度和反应时间等对微球制备的影响,得出最佳的反应条件。以微球的平均粒径和溶胀度为指标,对微
2、球进行表征,并对微球的吸附性能,粒度分布、形貌、红外光谱等进行考查。实验结果表明:在油水相体积比为4:1、乳化剂用量为0.009g/ml油、环氧氯丙烷0.625ml/g淀粉、淀粉质量浓度为4%、反应时间4h的条件下所得的淀粉微球对次甲基蓝的吸附为1.822mg/g,可用作良好的药物载体和吸附剂,溶胀度为339%,平均粒径为37.9μm。关键词:淀粉微球;反相乳液交联;吸附性能II大连工业大学2010届本科毕业生论文ABSTRACTAsanidealmedicinevector,starchmicorpherehasdrawnmoreandmoreattention
3、inthestudyofitssynthesisandfunctionalmodification.Peopleintendtofindtherightwaytosynthesisthestarchmicorpherethathasbetterstability.Theimprovementofperfermaceinloadingandreleasingofmedicine,aswellasit’sapplicationinmodernpharmaceuticalpreprationsareveryimpotantInthisarticleweusethesol
4、ubestarchastherawmaterial,epichlorohydrinasthecosslinker,span60astheemulsifierandthesoybeanoilastheoilphase.Weusetheinverseemulsiontosynthesisthestarchmicorphere.Inthecourseofthestudy,weputmuchattentiononthevolumeratioofthewaterphaseandtheoilphase,theamountoftheemulsifier,theamountand
5、thespeciesofthecosslinker,theconcentrationofthestarchandthereactiontime.Andallthefactor’seffectiononthesynthesisofthestrachinordertofindoutthebestreactionconditions.Usetheavreagesizeandtheseellingdegreetocharacterisethestarchmicorphere.Moreovertesttheadsorption,sizedistribution,appear
6、ance,IRofthesynthesisedstrachmicorphere.Theresultsshowthat:Intheconditionofthethevolumeratioofthewaterphaseandtheoilphaseis4:1,theamountoftheemulsifieris0.009gofeveryoil,theamountoftheepichlorohydrinis0.625ml/g(strach),thestrachconcentrationis4%andthereactiontimeis4h,theadsorptionrati
7、oofthesynthesisedstrachmicorphereis1.822mg/gwhichindicatethatitwillperfermatgoodinactingasthemedicinevectorandadsorbent.Keyword:strachmicorphere;inverseemulsioncrosslinking;adsorptionII大连工业大学2010届本科毕业生论文目录前言4第一章文献综述51.1微球的应用51.1.1微球在靶向给药中的应用51.1.2微球在组织工程中的应用51.2微球的分类61.3淀粉微球的研究进展61.3.
8、1淀粉微球