genetics to know ourselves, human genome introduction外语英文电子书

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1、TOKNOWOURSELVES❖THEU.S.DEPARTMENTOFENERGYANDTHEHUMANGENOMEPROJECTJULY1996TOKNOWOURSELVES❖THEU.S.DEPARTMENTOFENERGYANDTHEHUMANGENOMEPROJECTJULY1996ContentsFOREWORD.............................................................2THEGENOMEPROJECT—WHYTHEDOE?................................4Ab

2、oldbutlogicalstepINTRODUCINGTHEHUMANGENOME....................................6TherecipeforlifeSomedefinitions..........................................................6Aplanofaction..........................................................8EXPLORINGTHEGENOMICLANDSCAPE.................

3、................10MappingtheterrainTwogiantsteps:Chromosomes16and19.....................................12Gettingdowntodetails:Sequencingthegenome...............................16Shotgunsandtransposons.................................................20Howgoodisgoodenough?..............

4、..................................26Sidebar:ToolsoftheTrade..................................................17Sidebar:TheMightyMouse.................................................24BEYONDBIOLOGY......................................................27InstrumentationandinformaticsSmal

5、lerisbetter—Andotherdevelopments....................................27Dealingwiththedata.....................................................30ETHICAL,LEGAL,ANDSOCIALIMPLICATIONS...........................32AnessentialdimensionofgenomeresearchForewordTTHEENDOFTHEROADinLittlehasbeenrapi

6、d,anditisnowgenerallyagreedCottonwoodCanyon,nearSaltthatthisinternationalprojectwillproduceLakeCity,AltaisaplaceofthecompletesequenceofthehumangenomeAnear-mythicrenownamongbytheyear2005.skiers.IntimeitmaywellAndwhatismoreimportant,thevalueassumesimilarstatusamongmolecularoftheprojectal

7、soappearsbeyonddoubt.geneticists.InDecember1984,aconferenceGenomeresearchisrevolutionizingbiologythere,co-sponsoredbytheU.S.Departmentandbiotechnology,andprovidingavitalofEnergy,ponderedasinglequestion:DoesthrusttotheincreasinglybroadscopeofthemodernDNAresearchofferawayofdetect-biolo