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1、DOI:10.1158/0008-5472.CAN-06-1382OligomannurarateSulfate,aNovelHeparanaseInhibitorSimultaneouslyTargetingBasicFibroblastGrowthFactor,CombatsTumorAngiogenesisandMetastasisHuajunZhao,HaiyingLiu,YiChen,etal.CancerRes2006;66:8779-8787.PublishedonlineSept
2、ember1,2006.UpdatedVersionAccessthemostrecentversionofthisarticleat:doi:10.1158/0008-5472.CAN-06-1382SupplementaryAccessthemostrecentsupplementalmaterialat:Materialhttp://cancerres.aacrjournals.org/content/suppl/2006/09/11/66.17.8779.DC1.htmlCitedArt
3、iclesThisarticlecites38articles,17ofwhichyoucanaccessforfreeat:http://cancerres.aacrjournals.org/content/66/17/8779.full.html#ref-list-1E-mailalertsSignuptoreceivefreeemail-alertsrelatedtothisarticleorjournal.ReprintsandToorderreprintsofthisarticleor
4、tosubscribetothejournal,contacttheAACRSubscriptionsPublicationsDepartmentatpubs@aacr.org.PermissionsTorequestpermissiontore-useallorpartofthisarticle,contacttheAACRPublicationsDepartmentatpermissions@aacr.org.Downloadedfromcancerres.aacrjournals.orgo
5、nJuly24,2012Copyright©2006AmericanAssociationforCancerResearchDOI:10.1158/0008-5472.CAN-06-1382ResearchArticleOligomannurarateSulfate,aNovelHeparanaseInhibitorSimultaneouslyTargetingBasicFibroblastGrowthFactor,CombatsTumorAngiogenesisandMetastasis11,
6、21221HuajunZhao,HaiyingLiu,YiChen,XianliangXin,JingLi,YongtaiHou,1111,21ZhonghuaZhang,XiongwenZhang,ChengyingXie,MeiyuGeng,andJianDing1DivisionofAnti-TumorPharmacology,StateKeyLaboratoryofDrugResearch,ShanghaiInstituteofMateriaMedica,ChineseAcademyof
7、Sciences,Shanghai,P.R.Chinaand2DepartmentofPharmacologyandGlycobiology,MarineDrugandFoodInstitute,OceanUniversityofChina,Qingdao,P.R.ChinaAbstractproteinsfoundintheextracellularmatrix,playkeyrolesintheself-assembly,insolubility,andbarrierpropertiesof
8、thebasementInhibitorsoftumorangiogenesisandmetastasisareincreas-membraneandextracellularmatrix(2–5).Heparanase,amamma-inglyemergingaspromisingagentsforcancertherapy.lianendo-h-D-glucuronidase,capableofpartiallydepolymerizingRecently,heparanaseinhibit
