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1、EULARBD治疗建议目的和方法基于循证医学证据，建立治疗BD的EULAR建议专家委员会（风湿病专家9人、眼病专家3人、内科学专家1人、皮肤病专家1人、神经病学专家1人）文献检索：MedlineandCochraneLibrarydatabase(1966~2006)1.EyeinvolvementAnypatientwithBDandinflammatoryeyediseaseaffectingtheposteriorsegmentTreatmentregimeincludesazathioprine(RCT)(2.5mg/kg/d)andsyste
2、miccorticosteroids(白内障、青光眼).5.GastrointestinalinvolvementThereisnoevidence-basedtreatmentthatcanberecommendedforthemanagementofgastrointestinalinvolvementofBD.Agentssuchassulfasalazine,corticosteroids,azathioprine,TNFaantagonistsandthalidomideshouldbetriedfirstbeforesurgery,exce
3、ptinemergencies.6.JointinvolvementInmostpatientswithBD,arthritis(mildandtransient,nonerosive,largejoints)canbemanagedwithcolchicine(1-2mg/d)(2RCT).7.NeurologicalinvolvementTherearenocontrolleddatatoguidethemanagementofCNSinvolvementinBD.Forparenchymalinvolvementagentstobetriedma
4、yincludecorticosteroids(MP静脉冲击1g/d,3-7d),IFNa,azathioprine,cyclophosphamide,methotrexateandTNFaantagonists.Forduralsinusthrombosiscorticosteroidsarerecommended.8.CyclosporineAneurotoxicityCyclosporineAshouldnotbeusedinBDpatientswithcentralnervoussysteminvolvementunlessnecessaryf
5、orintraocularinflammation(3casecontrolstudies).9.MucocutaneousinvolvementThedecisiontotreatskinandmucosainvolvementwilldependontheperceivedseveritybythedoctorandthepatient.Mucocutaneousinvolvementshouldbetreatedaccordingtothedominantorcodominantlesionspresent.Topicalmeasures(ie,
6、localcorticosteroids)shouldbethefirstlineoftreatmentforisolatedoralandgenitalulcers.9.MucocutaneousinvolvementAcne-likelesionsareusuallyofcosmeticconcernonly.Thus,topicalmeasuresasusedinacnevulgarisaresufficient.Colchicineshouldbepreferredwhenthedominantlesioniserythaemanodosum.
7、Legulcers(post-thrombotic,vasculitic)inBDmighthavedifferentcauses.Treatmentshouldbeplannedaccordingly.Azathioprine,IFNa(1RCT)andTNFaantagonists(1RCTforetanercept)maybeconsideredinresistantcases.(Thalidomide)Categoryofevidence,strengthofrecommendationsandlevelofagreementofrecomme
8、ndationsRecommendationno.CategoryofevidStrength
