英文医学课件：7 Immune system免疫系统.ppt

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1、Chapter10Immunesystemimmunologicdefencefunctionimmunesurveillancefunctionimmunehomeostasis1.Components1)  Cells①Lymphocyte:a.T-lymphocytes:cytotoxicTcell:TcC-killthetumorcell,virusinfectivecellandforeigncellhelperTcell:ThC-promotesactivityofBLCandTcCsuppressorTcell

2、:TsC–regulatethefunctionofBLCandTCb.B-lymphocytes:becomeintoplasmacellc.NKcell:counteractvirusinfectivecellandtumorcell②Plasmacell③antigenpresentingcell:a. dendriticcell:BloodDCLangerhanscellinterstitialcellveiledcellinterdigitatingcellb.macrophage:Mononuclearphagoc

3、yticsystem④othercells:granulatedcellmastcellbloodplateletblood-bornestemcell2)    Lymphoidtissue---reticularT:reticularcell:stellate-shapedwithprocessestoformnetworkreticularfiber---lymphocytes,macrophage,plasmacellandmastcella.DiffuseLT:noclearboundarymainlyconsist

4、sofTLCpostcapillaryvenules:-highendothelialvenules-openingforLCenterLTfrombloodb.Lymphoidnodule:sphericalorovoidhaveclearboundariesmainlycomposedofBLCgerminalcenter:stainedpale*primaryLN→secondaryLN3)LymphoidorgansCentrallymphoidorgans:thymus,bonemarrowdevelopedearl

5、ierblood-bornestemcellcomesfromyolksacmicroenvironment→proliferationpromotingsendLCtoPLDandLTtwoweeksbeforeborneb.Peripherallymphoidorgans:lymphnode,spleenandpalatinetonsildevelopedlaterLCcomefromCLOcellproliferationneedantigenstimulating-antigendependentplaceforimm

6、unereactions2.thymusStructureofthymus---capsule:CT→interlobularseptum---cortex:dark-staining---medulla:lighter-staining---consistsofthymicepithelialcell,thymicstromalcellandthymocytesthymus1)cortex:---thymicepithelialcell(epithelialreticularcell):subcapsularepitheli

7、alcell:/flattened/secretβ2-microglobulin,thymosinandthymopoietininterdigitationdendriticcell:/moreprocesses/MHCantigen---thymocyte:differentstagesofLClargeLC(prethymocyte):superfacialcortexcommonthymocyte:deepcortex-85-90%2)medulla:---epithelialreticularcellmedullar

8、yepithelialcell:secretthymosinthymiccorpuscleepithelialcell---thymocyte,macrophagethymiccorpuscle:/sphericalorovoid,30-50uminD/concentrica