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《双次灌注法超声造影对兔VX2微小肝癌的观察-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华医学超声杂志(电子版)2014年3月第11卷第3期ChinJMedul订as0und(Elec仃DnjcEdition),March2014,Vol11,No3·63··基础研究·双次灌注法超声造影对兔VX2微小肝癌的观察董晓宇冯卉李志艳刘阳冯松皋月娟赵红伟刘庆【摘要】目的研究超声造影不同灌注法对直径<1o.omm的兔VX2微小肝癌的检出率。方法将VX2瘤细胞接种于新西兰白兔大腿外侧皮下,制成荷瘤种兔并传代。将种兔VX2肿瘤在无菌条件下制成小瘤块,植入兔肝实质较厚处,制成带有VX2肿瘤的新西兰白兔3O只,30只VX2肝肿瘤的新西兰白兔,分别经外周静脉采用单次和双次灌注法注射造影剂,与
2、动物肝大体病理切面对照,观察不同造影方法检出微小肿瘤的敏感度。结果30只动物肝脏大体病理检查共检出41个微小肿瘤(其中3.0~5.0mm病灶l5个,5.0~10.0mm病灶26个)。荷瘤兔肝VX2微小肿瘤超声造影增强方式呈“快进快退”表现,即在动脉相迅速增强,门脉相开始廓清,延迟相明显低于周围正常肝实质。其中单次灌注法共检出病灶数量为32个,其中3.0~5.0mm病灶7个,5.0~10.0mm病灶25个;双次灌注法共检出病灶数量为39个,其中3.0~5.0mm病灶l3个,5.0~10.0mm病灶26个。单次和双次灌注法对微小肿瘤检出率分别为78%(32/41)和95%(39/41),差异
3、具有统计学意义(值为5.150,P值为0.023)。单次灌注法与双次灌注法对3.0~5.0mm病灶检出率分别为47%(7/15)和87%(13/15),差异具有统计学意义()c2值为5.400,P值为O.025),对5.0~10.0mm病灶的检出率分别为96%(25/26)和100%(26/26),差异无统计学意义(值为1.020,P值为0.500)。结论双次灌注法超声造影显著提高了微小肝癌(尤其是直径<5.0toni病灶)的检出率。【关键词】肝肿瘤;超声检查;造影剂Contrast·enhancedultrasoundwithdoubleperfusionmethodindetecti
4、onofrabbitVX2micro-hepatocellularcarcinomaDongXiaayu.FengHui,LiZhiyan.LiuYang,FengSong,GaoYuejuan.ZhaoHongwei,LiuQing.DepartmentofUltrasound,the302"HospitalofChinese.Beijing100039,ChinaCorrespondingauthor:LiZhiyan,Email:lzyyuer@sina.com[Abstract]ObjectiveTostudythedetectionrateofcontrast-enhanced
5、ultrasound(CEUS)withdifferentperfusionmethodsonrabbitVX2smallhepatocellularcarcinomalessthan10.0toni.MethodsVX2tumorcellswereinoculatedintothesubcutaneoustissueofNewZealandrabbit’sthi曲.Thentheplanttumorwerecutintosmallblocksundersterileconditionsandtransplantedintohepaticparenchymain30NewZealandr
6、abbi~.Thecontrastmediawasinjectedthroughperipheralveinbysingleanddoubleperfusionmethods.Thedetectionrateoftwomethodswerecompared.ResultsTherewere41hepatocellularcarcinomalesionsinthe30rabbits.Therewere15lesionswithsizebetween3.0mmand5.0iiun,and26lesionsbetween5.0lnrnand10.0mmindiameter.OnCEUS,the
7、VX2tumorpresentedfast-inandfast·outpattern.Inarterialphase,thelesionwasenhancedrapidly.Inportalvenousphase,contrastbegantowashoutfromthecarcinoma.Indelayphase,theenhancementoflesionwassignificantlylowerthanthesurroundi
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