前循环TIA患者血清总胆红素水平与ABCD2评分-论文.pdf

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1、30脑与神经疾病杂志2014年第22卷第l期●论著●前循环TIA患者血清总胆红素水平与ABCD2评分叶子明刘莹秦超王天保覃慧慧【摘要】目的探讨动脉粥样硬化(As)性前循环短暂性脑缺血发作(TIA)患者血清总胆红素(T．Bil)水平与其ABCD2评分的相关性。方法收集前循环TIA患者133例进行ABCD2评分，根据评分分为低危亚组、中危亚组和高危亚组，收集其血清T．Bil水平资料，比较三组间血清T．Bil平均水平，分析血清T．Bil水平与ABCD2评分的相关程度及其临床意义。结果TIA患者血清T．Bil水平较对

2、照组显著降低，差异有统计学意义(P

3、，并与ABCD2评分呈负相关。【关键词】短暂性脑缺血发作；前循环；总胆红素；ABCD2评分中图分类号：R743．32文献标识码：A文章编号：1006·351x(2014)OI一0030-03Therelationshipbetweenserumt0talbilirubinlevelandABCD2scoreofthepatientswithanteriorcirculationTIAYEZi—m，L[U，QINChao，WANGTian—bao．Q，ⅣHui—hui．DepartmentofNeurology

4、，theFintAffiliatedHospitalofGuangxiMedicalUniversity，Nanning530021，ChinaCorrespondingauthor：QINChao，Email：m由c6639@126．con【Abstract】ObjectiveToinvestigatetherelationshipbetweenserumtotalbilirubin(T．Bil)levelandABCD2scoreofthepatientswithatheroselerosis(AS)an

5、teriorcirculationtransientischemicattack(TIA)．MethodsOnehundredandthirty—threepatientswereevaluatedbytheABCD2scoreandstratifiedintolow一，mid—andhigh—risksubgroups．SerumT．BillevelsweretestedinTIAandcontrolgroups．Thendifferenceswerecomparedandcorrelationswerea

6、nalyzed．Results①T．BillevelofTIAgroupwassignificantlyhigherthanthatofcontrolgroup(P<0．001)．TherehadsignificantdiferencesofT．Billevelamong3subgroups(P=0．0O4)，high—risksubgroup[(7．59±2．05)i．~mol／L]waslowerthanmid·risk[(9．45_+3．08)~mol／L]subgroupandmid—risksubg

7、roupwaslowerthanlow—risksubgroup[(11．53±2．26)I~mol／L](P<0．05foreach)；②ABCD2scorewasnegativelyrelatedtoT．Billevel(r一0．269，P=0．002)．ConclusionsTheserumT．BilleveldecreasesastheABCD2scoreincreasesandisnegativelycorrelatedtotheABCD2scoreofpatientswithASanteriorc

8、irculationTIAs．【Keywords】Transientischemicattack；Anteriorcirculation；Totalbilirubin；ABCD2score短暂性脑缺血发作(transientischemicattack，等提出的ABCD2评分较为全面、科学和简单易行，TIA)是I临床常见的急性缺血性脑血管疾病之一。已被AHA／ASA推荐为评估TIA患者预后及预测脑梗