HBV携带孕妇妊娠晚期HBVDNA载量及产褥期生活方式对产后转氨酶的影响.pdf

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1、新医学2014年7月第45卷第7期455临床研究论著HBV携带孕妇妊娠晚期HBVDNA载量及产褥期生活方式对产后转氨酶的影响黄兆明赵莹【摘要】目的探讨携带HBV孕妇在妊娠晚期的HBVDNA载量、产褥期每日睡眠时间、产褥期乙醇摄入对其产后转氨酶的影响。方法随机选择门诊产前检查HBsAg阳性的152例孕妇(研究纽)、HBsAg阴性的1】2名孕妇(对照组)，检测研究组妊娠晚期HBVDNA载量，测定2组产妇产后42d时A和AST水平。对2组产妇在产褥期内的睡眠时间、饮食结构进行随访，研究组中产褥期有摄入乙醇者设为A组，无

2、摄入乙醇者设为B组，对照组相应设为c、D组；另将研究组中产褥期睡眠时间少于8h／d者设为a组，达到或超过8h／d者设为b组，对照组中相应设为e、d组。研究组中，妊娠晚期HBV—DNA载量异常者设为E组，正常者设为F组。比较各亚组孕妇产后42d转氨酶水平。结果A组孕妇产后AST异常率明显高于B、c、D组(P<0．01)。a组孕妇产后ATJrr、AST异常率明显高于e、d组(P<0．01)，但与b组比较差异无统计学意义(P>0．05)。E组孕妇产后A、AST异常率明显高于F组(P均<0．05)。结论妊娠晚期HBVDN

3、A载量异常、产褥期摄入乙醇的携带HBV者，其转氨酶在产后容易出现异常。【关键词】乙型肝炎病毒携带者；孕妇；乙型肝炎病毒脱氧核糖核酸；丙氨酸基转移酶；天冬氨酸氨基转移酶；乙醇；产褥期睡眠时间EfectsofHBV-DNAloadduringlatepregnancyandpostpartumlifestyleofpregnantwomencarriedHBVonALTandASTlevelsafterdeliveryHUANGZhao—ming，ZHAOYing．DepartmentofObstetrics，Gua

4、ngzhouWomenandChildrenHealthCareCenter，Guangzhou510180，China．【Abstract】ObjectiveToinvestigatetheeffectsofHBV—DNAloadduringlatepregnancy，dailysleeptimeandMcoholintakeonAIJrrandASTlevelsafterpostpartum．MethodsIntota1．152pregnantwomenwithHBsAg(+)and112counterpar

5、tswithHBsAg(一)wererandomlyselectedfromtheoutpatientandallocatedintotheexperimentalandcontrolgroups．HBV—DNAlevelsduringlatepregnancyintheexperi—mentalgroupweredetected．AandASTlevelsat42dafterpostpartumweremeasuredandstatisticallycon—paredbetweentwogroups．Daily

6、sleeptimeanddietmycomponentsintwogroupswerefollowedup．Partici—pantsintheexperimentalgroupwerefurtherdividedintosubgroupsA(alcoholintake)andB(none)andeor—respondingsubgroupsCandDwereestablishedinthecontrolgroup．Intheexperimentalgroup，thosewithpostpartumdailysl

7、eeptime<8h／dwereassignedtosubgroupaand>8h／dtosubgroupb．andcorrespond—ingsubgroupseanddwereassignedinthecontrolgroup．WomenwithabnormalHBV—DNAloadduringlatepregnancyintheexperimentalgroupwereallocatedtosubgroupEandthosewithnormalHBV·-DNAloadtosub·-groupF．ALTand

8、ASTlevelsat42dafterpostpartumwascomparedamongdifferentsubgroups．ResultsTheincidenceofabnormalASTlevelsinsubgroupAwassignificantlyincreasedthanthoseinsubgroupsB，CandD(allP<0．O1)．Theinciden