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ID:52945292
大小:3.22 MB
页数:55页
时间:2020-04-02
《肿瘤代谢调节治疗.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、肿瘤代谢调节治疗石汉平FACS中山大学附属第一医院卫计委《医学参考报-营养学频道》卫计委《肿瘤代谢不营养杂志》中国肿瘤营养不支持治疗与业委员会庾黔娄,南齐,孱陵县令葡萄糖胞浆葡萄糖线粒体50%Cori丙酮酸三羧酸循环循环丙酮酸ATP乙酰辅酶A50%乳酸乳酸脂肪癌从口人Whendietiswrongmedicineisofnouse,Whendietisrightmedicineisofnoneed.膳食均衡,医生种田;营养丌好,仙丹无效!----AyurvedicProverb让食物成为你的药物!-------希波克拉底药食同源(饥为食,患为药)--------神农癌
2、从口出1.减少葡萄糖供给FosterR,etal.PLoSOne.2012;7(9):e45061.转移性乳腺癌患者原収灶及转移灶细胞表面葡萄糖调节蛋白78表达升高(cellsurface–localizedglucoseregulatedprotein78,GRP78)MiaoYR,etal.Inhibitionofestablishedmicrometastasesbytargeteddrugdeliveryviacellsurface-associatedGRP78.ClinCancerRes.2013;19(8):2107-16.FosterR,etal.PL
3、oSOne.2012;7(9):e45061.细胞活性肿瘤重量无病生存时间细胞数量MiaoYR,etal.ClinCancerRes.2013;19(8):2107-16.2.维持血糖稳定静脉注入葡萄糖后胰岛素分泌反应,(A)正常体重,(B)低体重,癌症患者胰岛素分泌显著低亍正常对照组(P<.05)TayekJA,et.al.,Metabolism.1997;46:140145SusanaRomero-GarciaR,etal.TumorcellmetabolismAnintegralview.CancerBiolTher.2011;12(11):939–948.Pr
4、oposedroleofmiR-451intheregulationofLKB1signalinginresponsetofluctuatingglucose.Twodifferentgrowthschemesoftumorspheroids(grayfilledcircle)withsameinitialsizeinresponsetofluctuatingandsteadyglucose(greensolidline).KimY,etal.miR451andAMPKmutualantagonismingliomacellmigrationandproliferat
5、ion:amathematicalmodel.PLoSOne.2011;6(12):e282933.促进葡萄糖氧化TPP丙酮酸脱氢酶脱羧酶复合物thiamine(opencircle)DCA(closedcircle)HanberryBS,BergerR,ZastreJA.High-dosevitaminB1reducesproliferationincancercelllinesanalogoustodichloroacetate.CancerChemotherPharmacol.2014;73(3):585-94大剂量维生素B1减少PDH磷酸化大剂量维生素B1降低
6、葡萄糖消耗和乳酸产生高剂量维生素B1降低线粒体跨膜电位提高凋亡蛋白酶caspase-3活性4.抑制乳酸代谢(糖异生途径,消耗6个ATP/葡萄糖)净消耗ATP:6-2=4乳酸丙酮酸葡萄糖×2×2肿瘤患者乳酸循环(肝)(Cori循环)增加葡萄糖乳酸葡萄糖乳酸丙酮酸乳酸丙酮酸葡萄糖×2×2×2×2(糖酵解过程,净产生2个ATP/葡萄糖)(肿瘤)(骨骼肌)SutendraG,MichelakisED.Pyruvatedehydrogenasekinaseasanoveltherapeutictargetinoncology.FrontOncol.2013;3:38.Miche
7、lakisED,etal.Dichloroacetateasapotentialmetabolic-targetingtherapyforcancer.BrJCancer.2008;99(7):989-94.5.提高脂肪比例Glucose/Lipid63/37vs25/75HuschakG,etal.Oliveoilbasednutritioninmultipletraumapatients:apilotstudy.IntensiveCareMed.2005;31(9):1202-8.PIK3CAmutationspecificglucosedepe
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