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1、乙型肝炎病毒感染临床结局与HLA-DR基因的相关性硏究［摘要］目的：探讨乙型肝炎病毒(HBV)感染临床结局与人类白细胞抗原DR(HLA-DR)基因间的相关性。方法：选择急性乙型肝炎(AHB)76例,慢性乙型肝炎(CHB)102例,乙肝后肝驶化(LC)38例，肝细胞癌(HCO34例，用聚合酶链反应-序列特异性引物法(PCR-SSP)检测HLA-DR基因型。结HLA-DR1基因型频率在LC和HCC组显著高于AHB组(x2=8.495,P二0.004),较CHB组也显著升高(x2=5.667,P=0.017)；HLA-DR8基因型发生频率在CHB、LC和HCC三个HBV慢性感染纟fl间无显著差异
2、(P二0.034)，而在AHB组显著低于HBV慢性感染纟R(x2=8.830,P=0.003)；HLA-DR13基因型频率在AHB组显著高于CHB组(x2=26.876,P=0.000)及LC和HCC组(x2=6.413,P=0.011),而LC和HCC组又高于CHB组(xc2=6.479,Pc=O.Oil)。结论：HLA-DR1基因型可能与HBV相关的肝硬化和肝细胞癌的发生有关，而HLA-DR8基因型则对IIBV感染的慢性化有促进作用，IILA-DR13基因型可有助于IIBV的清除，但在IILA-DR13阳性的IIBV慢性感染者发生肝硬化和肝细胞癌的风险增加。［关键词］乙型肝炎病毒：临床
3、结局；人类白细胞抗原DR基因［中图分类号］R512.6+2［文献标识码］C［文章编号］1673-7210(2008)11(b)-025-02StudyoftheassociationbetweentheclinicaloutcomesandHLA-DRgenesinthehepatitisBvirusinfectionsubjectsLIUFu-huil,LIJian~zhongl,LIChang-ying2,WANGYi-chengl(1.TeachingHospitalofMedicalCollegeofQingdaoUniversity,QingdaoHospitalforInfec
4、tiousDiseases,Qingdao266033,China;2.QingdaoBloodCenter,Qingdao266071,China)［Abstract］Objective:TostudytheassociationbetweentheclinicaloutcomesandHLA-DRgenesinthehepatitisBvirusinfectionsubjects.Methods:HLA-DRallelesin76casesacutehepatitisB,102caseschronichepatitisB,38caseslivercirrhosisand34hepato
5、cellularcarcinomawithIIBVinfection,werecletectedbypolymerasechainreaction-sequeneespecificprimer(PCR-SSP)technique.Results:ThefrequencyofHLA-DR1genewassignifiedntlyhigherinlivercirrhosisandhepatocellularcarcinomagroupthanthatinacutehepatitisB(x2=8.495,P二0.004)andthatinchronichepatitisB(x2=5.667,P二
6、0.017).TherewasnodifferenceinthefrequenciesofHLA-DR8geneamongchronichepatitis,livercirrhosisandhepatocellularcarcinomagroups(P=0.034),butthefrequencyinacutehepatitisBwassignificantlylowerthanthatinthechronicHBVinfectionsubjects(x2=8.830,P=0.003).ThefrequencyofHLA-DR13genewassignificantlyhigherinac
7、utehepatitisBthanthatinchronichepatitisB(x2=26.876,P=0.000)andthatinlivercirrhosisandhepatocellularcarcinoma(x2=6・413,P二0.011),andthefrequencyofIILA-DR13genewasmarkedlyhigherinlivercirrhosisandhepatocellularcarci
