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1、同期推量调强放疗与序贯推量调强放疗治疗老年局晚期非小细胞肺癌的效果比较［摘要］目的比较老年局晚期非小细胞肺癌(LA-NSCLC)患者采取同期推量调强放疗(SIB-IMRT)与序贯推量调强放疗(SEQ-IMRT)的效果。方法冋顾性分析徐州医学院附属医院2010年1月〜2014年10月住院的56例老年LA-NSCLC患者，随机分为治疗组(28例,采用SIB-IMRT)和对照组(28例，采用SEQ-IMRT)0比较两组患者放疗计划不同参数的剂量及两组患者的近期疗效和急性毒副反应。结果STB-TMRT组肿瘤靶区内生物
2、等效剂量(BED)(95.3±4.7)Gy高于SEQ-IMRT组的(86.4±3.2)Gy,差异有统计学意义(P0.05)；两组靶区肺受照相关体积、肺平均受照剂量、脊髓受照最大剂量、心脏受照相关体积比较，差异无统计学意义(P>0・05)o治疗组总有效率(CR+PR)为82.1%,对照组总有效率为46.4%,两组比较差异有统计学意义(卩0.05)。结论STB-TMRT与SEQ-TMRT治疗老年LA-NSCLC,前者可获得理想的剂量分布，可提高肿瘤靶区内的BED且未增加周围危及器官剂量，可提高近期疗效口急性毒副反
3、应无增加。［关键词］非小细胞肺癌；放射治疗；调强放疗；剂量学［中图分类号］R734.2［文献标识码］A［文章编号］1674-4721(2015)09(b)-0042-04EffectcomparisonofSIB-IMRTandSEQ-IMRTforthetreatmentofelderlypatientswithlocallyadvancednon-smal1cel1lungcancerWUYanglLILianglYUIIong-min21.DepartmentofRadiotherapy,Affilia
4、tedHospitalofXuzhouMedicalCollege,Xuzhou221002,China；2.PublicHealthofXuzhouMedicalCollegeSchool,Xuzhou221004,China[Abstract]ObjectiveTocomparetheradiotherapyeffectbetweenSIB-IMRTandSEQTMRTintreatingelderlypatientswithlocallyadvancednon-smallcelllungcancer(L
5、A-NSCLC)・Methods56PatientswithLA-NSCLCfromJanuary2010toOctober2014inourhospitalwereretrospectivelyanalyzed.Patientswererandomlydividedintotreatmentgroup(11=28)andcontrolgroup(n二28)・ThecontrolgroupweregivenSEQ-IMRTandthetreatmentgroupweregivenSIB-IMRT.Thenth
6、edosimetryofdifferentparametersinradiotherapyplans,efficacyandacutet.oxicitiesbetweentwogroupswascomparedrespectively.ResultsTheBEDoftumortargetzoneintreatmentgroupwas(95・3±4.7)Gy,significantlyhigherthanthatof(86.4±3.2)Gyincontrolgroup,andthedifferencewasst
7、atisticallysignificant(P0.05)•Therewerenostatisticallysignificantbetweentwogroupsintargetilluminatedlungvolume,meanlungdose,themaximumdoseofspinalcordi1luminated且ndheartilluminatedvolume(P>0.05)・Thetotalefficacyratewas82.1%intreatmentgroupand46.4%incontrolg
8、roup,thediffereneewasstatisticallysignificant(P0.05)•ConclusionComparingSTB-TMRTwithSEQTMRTintreatingelderlyLA-NSCLC,theformercanobtainidealdosedistribution,increasetheBEDoftumortargetzone,increaseinth
