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1、普贝生促足月妊娠宫颈成熟及引产的临床观察作者：沈雪艳，杨玉秀，方方，陈丽丽单位：河北省石家庄市第四医院【摘要】口的探讨普贝生促足月妊娠宫颈成熟及引产的临床效果及其延长放置时间的安全性。方法采用随机对照前瞻性研究方法，将止常胎头位足月妊娠具有引产指征、宫颈Bishop评分<5分，无阴道分娩禁忌证的孕妇90例随机分为3组，普贝生组、米索前列醇组、缩宫素组，每组30例。观察3组用药后宫颈成熟度改变、临产时间、分娩方式和母儿结局。结果用药12h普贝生组宫颈评分为(7.7±1.3)分，明显高于米索前列醇
2、组的(6.0±1.1)分和缩宫素组的(4.2±1.2)分(P<0.05)o用药至临产的时间普贝生组(16±8)h,明显短于米索前列醇组的(27±8)h和缩宫素组的(35±9)h(P<O.01)。用药24h后普贝生组引产总有效率为93.4%,与米索前列醇组的66.7%和缩宫素组的36.6%比较，差异有统计学意义(P<0.05)。阴道分娩率普贝生组为76.7%,米索前列醇组60%,缩宫素组40%,差异有统计学意义(P<0.0
3、5)0产后出血、总产程、新生儿结局3组间差异无统计学意义(P>0.05)。结仑普贝生对足月妊娠促宫颈成熟及引产效果显著，成功率高，且延长普贝生放置时间也安全有效。【关键词】普贝生；米索前列醇；缩宫素；宫颈成熟；引产ClinicalobservationontheclinicalefficacyandsafetyofprostaglandinE2suppositoryinpromotingcervixmatureintermpregnancyandlaborinduetionSHENXueyan,YANGYu
4、xiu,FANGFang,etal.TheFourthHospitalofShijiazhuang,Shijiazhuang050011,China【Abstract】ObjectiveToinvestigatetheclinicalefficacyandsafetyofprostaglandinE2suppositoryinpromotingcervixmatureintermpregnancyandlaborinduction.MethodsNinetypregnantwomenofsingletonpreg
5、nancy,cephalicpresentation,Bishopscore<5points,withindicationoflaborinduetionandwithoutvaginadeliverycontraindicationwererandomlydividedinto3groups,prostaglandinE2suppositorygroup(PropessTMgroup),misoprostolgroupandoxytocingroup,30pregnantwomenineachgroup.
6、Afteradministrationthechangeofcervicalmaturity,thetimeinlabor,postpartumhemorrhage,deliverystyleandoutcomeofmotherandneonatewereobservedandcomparedinthe3groups・Results12hoursbeforeadministrationtheBishopscore(7.7±1.3)inPropessTMgroupwassignificanthighe
7、rthanthat(6.0±1・1)inmisoprostolgroupandthat(4.2±1.2)inoxytocingroup(P<0.05)・Thetime(16&plusnm;8)hfromadministrationtoinlaborinPropessTMgroupwassignificantshorterthanthat(27&plusnm;8)hinmisoprostolgroupandthat(35±9)hinoxytocingroup(P<
8、;0.05).24hoursafterlaborinductionthetotaleffectiverateoflaborinductioninPropessTMgroupwas93.4%,whichwassignificantlyhigherthan66.7%inmisoprostolgroupand36.6%inoxytocingroup(P<0.05).The
