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1、复发性风湿症63例临床分析及1.5-3年随访结果梁东风黄烽张江林【摘要】目的提高对复发性风湿症临床特点、治疗方法和预后的认识。方法分析63例复发性风湿症患者的临床资料•观察他们对治疗的反应并对其进行】.5~3年的随访。结果本组患者平均发病年龄(40±11)岁,平均病程(8±7)年。主耍表现为巫发性急性关肖炎和(或)关少周围软组织炎症,全身大多数关修可累及,46%冇发作诱因,67%发作频率逐年增加oIHili体类抗炎药和改变病悄的抗风湿药对本症冇不同程度的疗效。5%患者的症状完全消失,90%长期反复发作,还冇5%进展为RA。结论复发性风湿症是一种主耍表现为复发性怎、性关方炎和(或)关
2、肖周围炎的临床综合征,靑每胺和磷酸氯嗪对本症冇效,其侦后存在多样性。【关键词】复发性风湿症;关石炎;关紡周围炎;治疗;预后Clinicalanalysisandfollow-upyearsof63palindromicrheumatismpatientsLIANGDong予ng,HUANGFeng,ZHANGJiang-lin・DepartmentofRheumatology.ChinesePLAGeneralHospital,Beijing100853,ChinaCorrespondingauthorHUANGFeng^Email:Jhiumg^301hospital.conuc
3、n[Abstract]ObjectiveIllisresearchisproposedtoimprovetherecognitionoftheclinicalfeatures,therapyandprognosisofpalindromicrheumatism.MethodsWeanalyzedtheclinicaldataof63palindromicrheumatismpatients.TTieirresponsetotherapywasobserved,andtheywerefollowedupfor1.5to3years.Results'Hieaverageonsetage
4、ofthepatientswas(40±l1)yearsandtheaveragediseasedurationwas(8±7)years,llieywerecharacterizedbyrecurrentattacksofsudden-onsetacutearthritisand(or)periarticulartissueinflammation,inwhichmostjointswereinvolved.In46percentofthepatients,theattackswereincitedbysomeevents.In67percentofthem,theattack
5、srecunredmoreandmorefrequently.Nonsteroidalanti-inflammatorydrugsanddiseasemodifyinganli-rheumaticdrugs(DMARDs)wasefleciveinvariantextents,topalindromicrheumatismpatients.Fivepercentofpatientsachievedcompleteremission.Ninepercentofthemhadrelapsesforalonglime.And5%ofthemevolvedtoRA.ConclusionP
6、alindromicrheumatismisasyndromecharacterizedbyrecurrentattacksofsudden-onsetacutearthritisand(or)periarticulartissueinflammation.HietherapyofDMARDs,especiallypenicillamineandchloroquinediphosphate,iseffectiveonthesyndrome.Hieoutcomesofpalindromicrheumatismisdiverse.【Keywords]Palindromicrheum
7、atism;Arthritis;Periarthritis;Therapy;Prognosis1944年,Hench和Rosenberg描述了34例患者表现出一系列相似的症状,复发性急性关节炎和(或)关节周围炎或关节旁炎,症状可持续几小时到几天,发作后不遗留关节功能障碍,他们将这一特殊临床表现的病症命名为复发性风湿症(palindromicrheumatism),并认为是一种独工的疾病。此后,一些研究发现部分本症患者可进展成类风湿关节炎(rheumatoidarth