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时间:2019-09-10
《替加环素相关急性胰腺炎》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、万方数据药物不良反应杂志2011年12月第13卷第6期删,December2011,Vol13.No.6替加环素相关急性胰腺炎赵程程闫素英’(首都医科大学宣武医院药剂科,北京100053)·安全用药·摘要替加环素(tigecycline)是一种新型广谱抗生素。为甘氨酰环素类(glycyclines)抗生素的首个药物,其化学结构与四环素相似。替加环素对革兰阳性茵和革兰阴性茵具有抗茵活性,用于治疗复杂皮肤、软组织感染和复杂腹腔内感染。通常,替加环素偶致急性胰腺炎,但近年资料表明,替加环素致急性胰腺炎有所增加。临床表现主要为恶心、呕吐、腹痛、
2、腹胀以及血清脂肪酶和淀粉酶水平升高。替加环素致胰腺炙的机制尚不明确,但由于替加环素的结构与四环素结构相似,推测替加环素是通过四环素致胰腺炎的同样机制引起急性胰腺炎。替加环素若引起胰腺炎,应立即停药,保持患者禁食状态,静脉给予足量液体,并给予其他对症治疗。替加环素使用期间,临床医师应密切观察患者有无胰腺炎的症状和体征,监测患者的血清脂肪酶和淀粉酶水平。关键词替加环素;急性胰腺炎中图分类号:R978.1文献标识码:A文章编号:1008-5734(2011)6-0363-04Acutepancreatitisassociatedwithtig
3、ecyclineZhaoChengcheng,YanSuying(DepartmentofPharmacy,XuanwuHospital,CapitalMedicalUniversity,&彬昭100053,China)ABSTRACTTigecyclineisanewbroad—spectrumantibiotic.Thisantibioticisthefirstclinicallyavailabledruginglycyclines.Itisstructurallysimilartotetracycline.Tigecyclinei
4、sactiveasainstGram—positiveandGram-negativebacteriaandisusedfortreatmentofcomplicatedskinandsofttissueinfectionsandcomplicatedintra—abdominalinfections.Generally,tigecyclinelesscommonlycau$e$acutepancreatitis.However,recentdataindicatethattigecycline-inducedacutepancreat
5、itishassomewhatincreased.Theclinicalpresentationoftigecycline·inducedacutepanereatitisisnausea,vomiting,abdominalpain,abdominaldistension,andelevationinserumlipaseandamylaselevels.Themechanismofpancreatitiscausedbytigecyclinsremainsunclear,butbecauseofthestructuralsimila
6、ritybetweentigecyclineandtetracycline,itisplausiblethattigecyclinemaybeviathesamemechanisma8tetracyclinetoprecipitateanacuteepisodeofpancreatitis.Ifpancreatitisisconsideredt0becausedbytigecycline.promptdiscontinuationoftigecyclinetherapyisnecessary.Themanagementoftigecyc
7、line-inducedpancreatitisincludesadministrationofIVfluids,avoidanceoffood,andothersymptomatictreatments.Cliniciansshouldobservepatientsforsignsandsymptomsofpancreatitis,andmonitorserumlipaseandamylaselevelsduringtreatmentwithtigecycline.KEYWORDStigecycline;aeuLepancreatit
8、is替加环素(tigecycline)是一种新型广谱抗生素,为首个用于临床的甘氨酰环素类(glycyclines)抗生素,其结构与四环素相似,于2005年6月被美国食品和药品管理局(FDA)批准E市。体外研
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