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ID:41417493
大小:56.71 KB
页数:3页
时间:2019-08-24
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1、Micro-porousorMicro-tubuleStructureinBoneTissueEngineeringScaffolds:AReviewXuLiangwei,JiangXianfeng*KeyLaboratoryofE&M(ZhejiangUniversityofTechnology),MinistryofEducation&ZhejiangProvinceAbstractAsoneofthekeyelementsoftissueengineering,micro-porousormicrotubulestmctureinbonetissueengineeringscaf
2、foldsnotonlyprovidesprotectionforcellproliferationandkeepingtheirrespectivefunctions,butalsoguidestissueregeneration,controlsorganizationalstructure.Therefore,thestudiesofmicro-porousormicro-tubulcstructureinbonetissueengineeringscaffc)ldsareincreasinglybeingtakenseriously.Severaltypesofmicro-po
3、rousormicrotubulestnictureinscaffoldswerehighlighted・Theirrecentresearchandapplicationwerediscussed.Theadvantagesanddisadvantagesofthemicrotubulestructuresgeneratedbydi氓renttechniqueswereanalyzedandsummarized.Thedevelopmenttendencywasprospected.KeywordsTissueengineering;Scaffold;Bonemicrotubules
4、*Correspondingauthor.E-mailaddress:XianfengJiang@zjut.edu.cn(JiangXianfeng).1•IntroductionControllablemicro-porousormicrotubulestructureinscaffoldsisthekeytodesignartificialboneskeletonthree-dimensionalstructure・Itshouldhavegoodbiocompatibilityandbiodegradability,andthree-dimensionalconnectedpor
5、ousstructurewithaspecificshape[l-5]・Therebyitfacilitatesthetransportofoxygenandnutrients,excludingofcellmetabolism,cellgrowthandreproduction[6-8].Accordingtothestudyoftissueengineeringscaffoldbytheresearchers,theresearchstatusofmicro-channelarchitectureintissueengineeringscaffoldsishighlighted・T
6、headvantagesanddisadvantagesofvariouspreparationtechniqueswereanalyzedandsummarized.Theirdevelopmenttrendswereprospected[9-12]・Thescopeofthepaperwiththreemainareasoffocusshowsasfollows:(1)Therequirementsandeffectoftissueengineeringformicro-porousormicrotubulestructureinscaffolds[14-15],(2)Manufa
7、cturingmicro-porousormicrotubulestnictureinmanualbonescaffoldswithtraditionalmethods,(3)Manufacturingmicro-porousormicrotubulestructureinmanualbonescaffoldswithCADandRP[13],(4)Thedesignofmanualbonemicro-porousormicrotubuleba
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