Regulation of megakaryocyte maturation and platelet formation巨核细胞成熟和血小板形成的调节

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1、JournalofThrombosisandHaemostasis,7(Suppl.1):227–234DOI:10.1111/j.1538-7836.2009.03398.xINVITEDREVIEWRegulationofmegakaryocytematurationandplateletformationD.BLUTEAU,*àL.LORDIER,*àA.DISTEFANO,*àY.CHANG,*àH.RASLOVA,*àN.DEBILI*àandW.VAINCHENKER*à*I

2、NSERM,U790,39rueCamilleDesmoulins,Villejuif;InstitutGustaveRoussy,39rueCamilleDesmoulins,Villejuif;andàUniversite´ParisXI,39rueCamilleDesmoulins,Villejuif,FranceTocitethisarticle:BluteauD,LordierL,DiStefanoA,ChangY,RaslovaH,DebiliN,VainchenkerW.Regulat

3、ionofmegakaryocytematurationandplateletformation.JThrombHaemost2009;7(Suppl.1):227–34.MKprogenitorshavealsobeendescribed.Terminaldifferen-tiationbeginswiththesynthesisofspecificplateletproteinsand11Summary.Eachdayineveryhuman,approximately1·10initiationo

4、ftheendomitoticprocess.plateletsareproducedbythecytoplasmicfragmentationofDuringmaturation,theMKcytoplasmbecomesverymegakaryocytes(MK),theirmarrowprecursorcells.Plateletsspecializedwiththedevelopmentofacomplexsystemofarethepredominatingfactorintheproces

5、sofhemostasisandmembranes,calledthedemarcationmembranesystem,andthrombosis.Recentstudieshaveshownthatplateletsalsoplayadifferenttypesofgranulesincludinglysosomes,densegranuleshithertounsuspectedroleinseveralotherprocessessuchasanda-granules.Proteinscont

6、ainedinthea-granules(special-inflammation,innateimmunity,neoangiogenesisandtumorizedsecretorygranules)canbesynthesizedorendocytosed.metastasis.ThelatephasesofMKdifferentiationidentifiedbySynthesizedproteins,suchasPF4orVWF,aredetectedearlypolyploidization,m

7、aturationandorganizedfragmentationofindifferentiationintheendoplasmicreticulumandtheGolgiinthecytoplasmleadingtothereleaseofplateletsintheblood2NcellsexpressingCD41(GPIIb/IIIa)andCD42(GPIb).streamrepresentauniquemodelofdifferentiation.TheTheirexpressioni

8、ncreasesandtheylocalizeintoa-granules.molecularandcellularmechanismsregulatingplateletbiogen-Someotherproteinsbindtomembranereceptors,likefibrin-esisarebetterunderstoodandmayexplainseveralplateletogentoGPIIb/IIIa,areendocytosedand