Redox reactivity of cerium oxide nanoparticles against dopamine

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1、JournalofColloidandInterfaceScience418(2014)240–245ContentslistsavailableatScienceDirectJournalofColloidandInterfaceSciencewww.elsevier.com/locate/jcisRedoxreactivityofceriumoxidenanoparticlesagainstdopamineAkhtarHayat,DanielAndreescu,GoncaBulbul,SilvanaAndreescu⇑DepartmentofChemistryandBiomo

2、lecularScience,ClarksonUniversity,Potsdam,NY,USAarticleinfoabstractArticlehistory:Theinteractionbetweendopamineandtheredoxactiveceriumoxidenanoparticles,ornanoceriawasReceived11September2013studiedusingasuiteofspectroscopicandsurfacecharacterizationmethods.ChangesinthechemicalAccepted3Decembe

3、r2013reactivityandconcentrationofdopamineuponexposuretonanoceriawasassessedinaqueoussolutionsAvailableonline11December2013andahumanphysiologicalfluid–humanserum.Theresultsindicatestrongattachmentofdopaminetothenanoparticlesurfacethroughoxidationfollowedbychemisorptionoftheoxidativeproductwithf

4、or-Keywords:mationofachargetransfercomplex.Suchoxidation/surfaceadsorptionprocessesbetweennanoceriaandNanoceriadopamineleadtoareductionoftheconcentrationoffreedopamineinaqueousenvironments.TheseDopaminefindingssuggestthattheredoxreactivityofnanoceriamayalterdopaminelevelsinbiologicalsystemsSur

5、faceoxidationSurfaceattachmentexposedtotheseparticlesandindicatetheneedforacomprehensiveassessmentofthepotentialneuro-Redoxreactivityofnanoparticleslogicalconsequencesthatmightresultfromintendedorunintendedexposuretotheseparticles.Ó2013ElsevierInc.Allrightsreserved.1.IntroductionAnopenandimpo

6、rtantquestioniswhethertheirredoxreactivity4+3+originatingfromthedualoxidationstate(Ce/Ce)canaffectCeriumoxide(CeO2)nanoparticlesornanoceriahaveshownpo-thelevelofelectroactivesubstancesinbiologicalsystems.Amongtentialascatalyticantioxidantsincellculturesandanimalmodelsthese,chemicalneurotransm

7、itterssuchasdopamine,serotonin,byactingassuperoxidedismutaseandcatalasemimetics[1].Thenorepinephrineandepinephrinearethefirstsusceptibletooxida-biologicalpropertiesofnanoceriaareaconsequenceofthedualtionbynanoceria.Thus,adetailedunderstandingo