幽门螺杆菌阳性功能性消化不良的治疗选择

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1、万方数据!邕庄堑坐宣盘查2螋!生蔓12查蔓≥髓·论著·幽门螺杆菌阳性功能性消化不良的治疗选择。·99·南京医科大学第一附属医院(南京210029}郜恒骏¨于莲珍缨餐孙亮张小勇吕秀玲赵志亲摘蔓目的：探讨根除幽门螺杆菌(HP)、改善胃动力及抗焦虑药对HP阳性功能性捎化不良(FD)症状的效果。方法：HP阳性的FDl60例随机的分为3个治疗组：胶体次枸橼酸铋(B)合并呋喃唑甯(F)厦羟氯苄青霉素(A)----联疗法(BFA方案。60例)、西沙必利(CIS，60倒)和多虑平(DXP．40倒)．对其疗效作前-曾性随机对照研究。结果：CIS总有效事显著高

2、于BFA(P<005)．DXP总有效率介于两者之间。临床类型中，CIS对运动障碍型FD疗敏优于BFA(P<0．01)；而对溃疡型FD，BFA比CIS效果更佳(P<005)；伴有焦虑、多疑、多梦厦严重失眠的女性FD，DXP常常收到良好的效果，并优于BFA或CIS(P

3、群的女性FD患者．推荐给予抗焦虑药治疗。关键词幽『J螺杆菌功能性消化不良治疗根除促动力药TherapeuticStudyOilHelicobacterPyloriPositiveFunctionalDysplasiaGaoHen90口n，MIuKun．Sun-Llang,et“DeparUr,entofGmtroenterole口．TheFirstAgl

4、iatedHospitalofN哪tagMedica!UuiversRyAbstractPurpose：Toinvestigatetheeffectofthreetherapiesonsy

5、mptomsoffunctiondysplasia(FD)withHPpositive，eradicationofHP，improvingdysmotilltyoranti—anxiety．Methods：160casesFDwithHPinfectionprovedbyureasetesttwarthen-starrystainingandculture(atleasttwoOutofthreeace[Dsitive)wererandomlyallocatedintothreegroups：bismuth-basedtriplethera

6、pycontainingfurazolidooeandarrloxine(BFAmethod．60cases)，Cisapride(CIS60cases)anddoxepirke(DXP-40cases)．Prosl】ec-tireandcomparedstudywasdonetoestimatetheireffectbyt-test．riditanalysis．Chi·squareteetandLo·gisticregressionanalysis．Results：TotaleffectiverateofCIS(70％)wassignif

7、icantlyhigherthanthatofBFA(40％)(P<005)．T0taleffectiverateofD)【PwasbetweenthatofCISandBFA．Inthesubgroupofclinicalpattens，theeffectofBFA(86．67％)onulcer-likedysplasiaw髂significantlyincreasedcomparedwiththatofCIS(46．15％)(P<0．05)，whereastheeffectofCIS(94．29％)ondysmotility-liked

8、ysplasiaw丑smuchbetterthanthatofBFA(24．2％)(P<0．01)．Inaddition，D)口wasoftengoodcandidatefor．thefemalepatientsaccompaniedwithanxiety，suspicious，lotsofdreamandsevereinsomnia．Therewerequitedifferenteffectsbetweenthreegroupsduetoage．sexanddurationofdisease．Conclusions：Itisnotneee

9、ssorytoeradicateHPasaroutinetherapeuticapproachonFDwithHPposiiive，however，itmightbemoreef