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1、浙江大学医学院陈季强教授Email:chenjq@zju.edu.cn2010-2011学年冬八周SectionⅥ.PharmacologicalBasisofTherapeutics药物治疗学基础(治疗学的药理学基础)IntroductionofBMSSectionⅥ.PharmacologicalBasisofTherapeuticsContentsChapter2.PharmacokineticsChapter3.FactorsinfluencingeffectofdrugChapter4.Anti-neoplasti
2、csChapter1.PharmacodynamicsBasicConceptofPharmacologyChapter4.Antineoplastics(抗恶性肿瘤药)SectionⅥ.PharmacologicalBasisofTherapeuticsPart2.AntineoplasticsincommonusePart3.Thetoxicreactionofantineo-plasticsandthecombinedtreatmentprinciplesContentsPart1.Thepharmacological
3、basisofantineoplasticsChapter4.Antineoplastic1.Classificationofantineoplastics:(1)classificationofantineoplasticsaccord-ingtochemicalstructureandsource:①Alkylatingagents(烷化剂:氮芥类等)②Antimetabolite(抗代谢物:MTX,5-FU等)③Antineoplasticantibiotic(抗肿瘤抗生素)④Antineoplasticplantdr
4、ugs(抗肿瘤植物药)⑤Hormones(激素及其拮抗剂)⑥Others(其他:铂类配合物和门冬酰胺酶)Part1.ThepharmacologicalbasisofantineoplasticsChapter4.Antineoplastic(2)classificationofantineoplasticsaccord-ingtobiochemicalmechanism:①drugsinterferingbiosynthesisofnucleicacid(MTX,5-FU,6-MP,etc.);②drugsdirectly
5、destroyingDNAstructureandfunction(HN2,CTX,DDP,MMC,BLM,etc.);③drugsinterferingtranscriptprocessandinhibitingRNAsynthesis(ADM,DACT);④drugsinterferingproteinsynthesisandfunction(VLB,VCR,paclitaxel,etc.);⑤drugsinterferingHormonebalance(prednison,androgen,estrogen,etc.)
6、Part1.Thepharmacologicalbasisofantineoplastics干扰激素平衡类:糖皮质激素,雄激素,雌激素,等2.Affectionofantineoplasticstocellgenerationcycle:(1)cellgenerationcycle:cellgenerationcyclecanbedividedinto:G0phase,G1phase,S(synthesis)phase,G2phaseandM(mitosis)phase.G0phasecellisnon-proliferat
7、ingcellpopulation,G1phasetoMphasecellareproliferat-ingcellpopulation.Part1.ThepharmacologicalbasisofantineoplasticsSPhaseDNAsynthesisG2PhasePostsyntheticphaseMPhaseMitosisG1Phase(Presyntheticphase)G0PhaseRestingphasePart1.Thepharmacologicalbasisofantineoplastics(2)
8、growthfraction(GF,生长比率):proliferatingcellpopulationGF=TotalcellpopulationGF值越大,对抗肿瘤药物越敏感;GF值越小,对抗肿瘤药物越不敏感.Part1.Thepharmacologicalbasisofantineop
