血管内皮生长因子C表达与临床Ⅰ期非小细胞肺癌淋巴结转移和化疗的关系

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1、血管内皮生长因子-C表达与临床Ⅰ期非小细胞肺癌淋巴结转移和化疗的关系【摘要】目的探讨临床I期(cI期)非小细胞肺癌(NSCLC)中血管内皮生长因子C(VEGF-C)的表达、微淋巴管密度(MLVD)、淋巴结转移及其与化疗的关系。方法应用免疫组化SP法检测cI期NSCLC癌组织、癌旁组织及正常肺组织中VEGF-C的表达，计数MLVD，检测血清VEGF-C蛋白含量，并结合病理淋巴结转移情况和化疗前、后VEGF-C蛋白含量的变化进行统计学分析。结果在NSCLC中，VEGF-C呈过度表达，与癌旁组织和正常肺组织相比差异有统计学意义(P<0.01);在癌

2、组织中淋巴结阳性组和淋巴结阴性组的VEGF-C阳性表达率(91.9%vs.76.7%)、MLVD[(20.0±4.8)vs.(10.6±2.2)]差异有统计学意义(P<0.01);血清VEGF-C蛋白含量与组织检测VEGF-C具有较好的相关性(r=0.848,P<0.01)，化疗患者化疗前血清VEGF-C蛋白含量(237±72.3)ng/mL较化疗后(178±69.2)ng/mL变化明显(P<0.01)。结论VEGF-C在cI期NSCLC中过度表达与淋巴结转移密切相关;血清VEGF-C蛋白含量测定是一种有效的VEGF-C检测方

3、法;化疗前、后血清VEGF-C蛋白含量的变化可以预测化疗效果。【关键词】非小细胞肺癌;血管内皮生长因子;微淋巴管密度;淋巴结转移　ABSTRACT:ObjectiveTostudythecorrelationofvascular8endothelialgrowthfactor-C(VEGF-C)expressionandlymphaticmicrovesseldensity(MLVD)withlymphaticmetastasisandsensitivityofchemotherapyinnon-smallcelllungcancer(NSCLC)

4、ofclinicalstageⅠ.MethodsVEGF-CexpressionandMLVDweredetectedincancertissues,para-cancertissuesofclinicalstageINSCLCandnormallungtissues.Theclinico-pathologicalresultsoflymphaticmetastasisandVEGF-Cproteinchangesafterchemotherapywereanalyzedstatistically.ResultsIncancertissuesofN

5、SCLC,theover-expressionofVEGF-Cwassignificantlyhigherthanthatinpara-cancertissuesandnormallungtissues(P<0.01).ThepositiveratesofVEGF-Cexpression(91.9%vs.76.7%)andMLVD[(20.0±4.8)vs.(10.6±2.2)]inlymphaticmetastasisgroupweresignificantlyhigherthanthoseingroupswithoutlymphaticm

6、etastasis(P<0.01).ThedetectionofVEGF-CinserumhadaclosecorrelationwithVEGF-Cproteinintissues(r=0.848,P<0.01).ThelevelofVEGF-Cproteininserumbeforechemotherapy(237±72.3)ng/mLwassignificantlyreducedafterchemotherapy[(178±69.2)ng/mL,P<0.01)].ConclusionOver-expressionofVEGF

7、-CiscloselyrelatedtolymphaticmetastasisinNSCLCofclinicalstageⅠ.ThedetectionofVEGF-Cinserumishelpfulinclinicalstage;changesofVEGF-Cproteininserumbeforeandafter8chemotherapycanpredicttheresultsofchemotherapy.　　KEYWORDS:non-smallcelllungcancer(NSCLC);vascularendothelialgrowthfact

8、or-C(VEGF-C);lymphaticmicrovesseldensity;lymphaticmetastasis