倏逝波光纤生物传感器系统理论分析与优化设计

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1、国防科学技术大学硕士学位论文倏逝波光纤生物传感器系统理论分析与优化设计姓名：王京生申请学位级别：硕士专业：光学工程指导教师：冯莹20071101国防科学技术大学研究生院学位论文关键词：光纤生物传感器，荧光信号分析模型，偶极子辐射理论，多模光波导的光线理论，倏逝波，光纤探针，连接器，优化设计第ii页国防科学技术大学研究生院学位论文ABSTRACTSensorsutilizingopficalfibersalebeingincreasinglyexploitedinindustrial，clinical，and

2、militaryapplications．Forthepurposeoftheoptimizationdesignoffiber-opticbiosensors，thesignalanalysisandtheoptimizationdesignofpivotalcomponentsarcde印lystudiedinthethesis．Firstly,byusingthetheoryoftheradiationofdipolesplacedwithinamultilayersystemandmyanalysi

3、sofmultimodeopticalwaveguides，theanalysismodelsoffluorescencesi掣lalarepresented．Withdetaileddescriptionoftheprinciplesoffluorescenceimmunoassaysfiber-opticbiosensors，themultilayersystemusedforanalysisoffluorescencesignalisproposed．Basedonthetheoryoftheradi

4、ationofdipolesplacedwithinmultilayersystem,theoriginalpowerdistributionsoffluorescenceemissiontogether、)I，imthecouplingefficiencyofthefiberprobealederived．Byusingtherayanalysisofmultimodeopticalwaveguides，theoreticalmodels，suchasthenormalizedpowerdistribut

5、ionsofthefluorescenceinthefiberprobe，thetransmissionefficiencyofthefiberprobe，thenormalizedoutputfluorescencepowerdistribmionsofthefiberprobe，thecollectionefficiencyofthefiberprobe，theeffectivecollectionefficiencyofthefiberprobe，theestimateoutputfluorescen

6、cepowerofthefiberprobeandthedetectedpowerofthesystemarepresented．硼豫theoryprovidedaboveisusefulfortheoptimizationdesignoffluorescenceimmnnoassaysfiber-opticbiosensors．Secondly,anewconnectorisdesignedandmanufactured．Inordertokeepawaythedisturbancetothedetect

7、ionoftheconstructedevanescentwave-basedopticalfiberbiosensorfromtheconnector,someconfigurationsofthebiosensorsareanalyzed．Thenthenewlydesignedconnectortogetherwithitstransformationmatrixisproposed．Onthepurposeofachievingthebestusageofthefluorescencesignala

8、ndmaximizingtheinterposition-avulsiontolerancesofthefiberprobe,themethodforchoosingpivotalcomponentsofthenewconnectortogetherwithitscriticalencapsulationparametersisprovided．Allthefinishedworkmentionedaboveis