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1、889C-T）基因型与冠心病的关系鱼堕医学07年第22卷第6期LaboratoryMedicine2007,Vol22.No6文章编号:1673?8640(2007)06-0703-04中图分类号:Q753文献标识码:A甘肃汉族人群白细胞介素1启动子(一889C/T)基因型与冠心病的关系张志明,居军,徐向红(1.兰州大学临床医学院,甘肃兰州730000;2.甘肃省人民医院检验中心,甘肃兰州730000)-703?摘要:目的探讨白细胞介素.1ot(IL.1ot)启动子一889C/T基因型与冠心病(CHD)的关系.方法采
2、用聚合酶链反应一限制性片段长度多态性(PCR—RFLP)检测98例CHD和131名健康者IL.1ot一889C/T位点基因型.结果IL.1ot一889位点在该人群中的基因型频率分布CC为183/229(79.9%),CT为45/229(19.70%),TT为1/229(0.04%),等位基因C为411/458(89.70%),T为47/458(10.30%).CHD组CT基因型与对照组比较差异有统计学意义(P<0.01).心肌梗死组CT型与对照组比较差异有统计学意义(P<0.01),而心绞痛组中CT型与对
3、照组比较差异无统计学意义(P>0.05),CHD组中CT型基因患心肌梗死的危险度是患心绞痛的2.02倍[比值比(OR)=2.02,95%可信区问(CI):1.05～3.89,P<0.05].结论l1.1ot启动子一889C/T位点存在基因多态性,T等位基因可能是甘肃汉族人群心肌梗死的易感基因.关键词:白细胞介素一1;基因多态性;冠心病Thecorrelationbetweengenotypesattheposition--889C/Tinthepromoterofinterleukin-1alphaand
4、coronaryheartdiseaseinGansuprovinceHanpopulationZHANGZhiming,.,UJun,XUXianghong'.(1.CollegeofClinicalMedicine,LanzhouUniversity,GansuLanzhou730000,China;2.CenterforClinicalLaborato?ry,thePeople~HospitalofGansuProvince,GansuLanzhou730000,China)Abstract:Objective
5、Toinvestigatethecorrelationbetweenthedifferentgenotypesattheposition一889C/Tinthepromoterofinterleukin一1ot(IL一1ot)andtheseverityofcoronaryheartdisease(CHD).MethodsThegenotypeofIL一1ot(一889C/T)from98patientswithCHDand131healthycontrolswereanalyzedbypolymerasechain
6、reactionre—strictionfragmentlengthpolymorphism(PCR—RFLP).ResultsThefrequenceofgenotypeCCinGansuprovinceHanpopulationwere183/229(79.9%),CT45/229(19.7%)andTrr1/229(0.04%).ThefrequenceofalleleCwas411/458(89.7%),T47/458(10.3%).AsignificantincreasewasfoundfortheIL一1
7、otgenotypeCTinCHDpatientscomparedwithcontrols(P<0.01).TherewassignificantdifferenceingenotypeCTbetweenmyocardialinfarctiongroupandcontrols(P<0.01).ButtherewasnosignificantdifferenceingenotypeCTbetweenanginapectorisgroupandcon—trois(P>0.05).Therelativer
8、iskofmyocardialinfarctiongroupwithgenotypeCTwas2.02timestoanginapectorisgroup(oddsratio[OR]=2.02,95%confidenceinterval[CI]:1.05—3.89,P<0.05).ConclusionsThepolymor-phismof
