成人与儿童急性白血病患者凝血、抗凝及纤溶指标变化研究

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1、授予单位代码１００８９１学弓则ｉ胃号１３５４６＾？Ｗｒ店钟＊巧多ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕ｉ学位论文在职科学学位成人与儿童急性白血病患者凝血、抗凝及纤溶指标变化研巧学位申请人；高羽高ｆ师：宋淑霞教授‘史敏主任技师专业：免疫学二级学院；基础医学院２０１５年１０月河北医科大学学位论义使用授权及知识产权归属承诺的指导下。本学位论文在导师（或指导小组），由本人独立完成本学位论文研究所获得的研究成果，其知识产权归河北医科大学所、公开和使用。凡发表有。河北

2、医科大学有权对本学位论文进行交流一，与学位论文主要内容相关的论文，第署名为单位河北医科大学试验材料、原始数据、申报的专利等知识产权均归河北医科大学所。有。否则，承担相应法律责任：妍：级学院领导盖章研究生签名：奏曼师签章７鳥寺珠１巧鱗Ｉ、年月河北医科大学硏究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加标注和致谢等内容外，文中不包含其他人已经。本论文由本人发表或撰写的研究成果，指导教师对此进行了审定独立撰写。，文责自负＂＂＂艇＇：夺研究生签名：鳥莉烏导师签章ｐ？ｉ＾Ｍｒ年ｆ月

3、日目录中文摘要·················································································1英文摘要··················································································4英文缩写····································································8研究论文成人与儿童急性白血病患者凝血、抗凝及纤溶指标变化研究前言

4、··················································································9资料与方法········································································10结果·············································································11附表······································

5、···········································13讨论·················································································16结论·················································································21参考文献································································

6、···········21综述急性白血病的凝血特征······················································24致谢·················································································37个人简历·················································································38中文摘要成人与儿童急性白血病患者凝血、抗凝及纤溶指标变化研究

7、摘要目的：急性白血病（AL）是发生于造血干细胞的恶性克隆性疾病，主要分为急性髓系白血病（AML）及急性淋巴细胞白血病(ALL)。在全国恶性肿瘤中,白血病的死亡率可占第六位(男性)和第八位(女性),而在儿童至35岁以下的人群中则占第一位。出血已被证明是急性白血病早期致死的重要原因。临床上常以实验室凝血指标的高低帮助判断出血可能性。然而，有关凝血、抗凝、纤溶机制的研究在急性髓系白血病与急性淋巴细胞白血病之间、儿童急性白血病与成人急性白血病患者之间以及急性白血病患者治疗前后之间尚未完全阐明。本研究通过观察急性髓系白血病与急性淋巴细胞白血病、儿童急性白血病与成人急性白

8、血病患者血浆凝血、抗凝、纤溶指标水平变