cd2ap与wt1在原发性肾病综合征肾小球的表达与意义

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1、英文摘要TheExpressionandSignificanceofCD2APandWT1inGlomeruliofPatientswithPrimaryNephroticSyndromeABSTRACTObjective：Nephroticsyndrome(NS)manifestsitselfinmassiveproteinuria,hypoalbuminemia，edemaandhyperlipidemia．Theintegratedstructureandfunctionoftheslitdiaphragm(SD)is

2、particularlycriticalfortheoccurrenceofproteinuria．CD2AP(CD2associatedprotein)iSakindofprotein10catedinSDwhichiSrelatedwithcytoskeletonassembly,cellsignaltransductionandapoptosisofpodocyte．Wilms’tumor1(WTI)asatranscriptionregulatoryfactorplaysanimportantroleinthemai

3、ntenanceofnormalpodocytefunction．OurstudyistoinvestigatetheexpressionanddistributionofCD2APandWT1(bYimmunohistochemistry、)inglomemliofpatientswithprimarynephroticsyndrome，andtocarryouttherelmiveresearcheswithtrialindexcommonlyusedin24-hoururinaryprotein，serumcreati

4、nine，glomerularsclerosisrate，SOastodiscussthepossibleeffectofCD2APandTT巾●’·^·‘WlintlaeoccurrenceoIproteinuria．Methods：(1)Eightypatientsdiagnosedasprimarynephroticsyndromewereinvolvedinthisstudywithanaverageage(39．644-16．3years)，50casesofmale，30casesoffemale。Basedon

5、pathologicalclassificationallpatientsare5英文摘要dividedintofourgroups(20casesineachgroup)：glomerularminimalchangegroup(MCN)，IgAnephropathygroup(focalproliferativesclerosingIgAnephropathyin8patients，mildmesangialproliferativeIgAnephropathyin1cases，severemesangialprolif

6、erativeIgAnephropathyin1patients)，membranousnephropathygroup(18casesinphaseI，2casesinphase2)，focalsegmentalglomerulosclerosisgroup(2casesofthetoptype，2casesofumbilical-based，16casesofnon-special-type)．(2)10specimensofrenaltissueinpatientswithnormalrenaltissueremote

7、carcinoma(5casesofmale，5casesoffemale)formedthecontrolgroup．(3)Collectedurineandserumsamples，measured24-hoururinaryprotein，serumcreatinine，serumalbumin．CD2APandWT1expressionindex(EI)aredetectedbyMoticMed6．0imageanalysissystem．Countingtheglomerularsclerosisratebyglo

8、merularlightmicroscopy(thenumberofscleroticglomeruli／thetotalnumberofglomerular×100％)．(4)TheestimatesofCD2APand、W1expressionweremathematicallyana