聚合物—盐双水相体系液液相平衡与其在枸杞多糖分离纯化中的应用

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1、江苏大学硕士学位论文ABSTRACTInrecentyears，aqueoustwo-phaseextractiontechnologyhasbeenbecomeanimportantseparationandpurificationtechnologyforbioactivesubstancesandnaturalproductsowingtotheadvantagesofsimple，greenandhighefficiencyinextraction．Accordingtothetypeofphase—formingsubstances，aqueoustwo—phasesystem(

2、ATPS)Canbedividedintopolymer-polymersystem，polymer—saltsystem，hydrophilicorganicsolvent—saltsystemandionicliquid—saltsystem．However,thesesystemshavesomedifficultiesinindustrializationbecauseoftheproblemswithhighviscosityinpolymer—polymersystems，instabilityofvolatileorganicsolventandhighcostofionic

3、liquid．Butpolymer-saltsystemshavebecomeoneofthemostcommonATPSusinginseparationandpurificationofbiologicalmaterialduetotheadvantagesoflowerviscosityandcost，goodbiocompatibility．Theresearchofliquid—liquidequilibriumisthefoundationforthedevelopmentofaqueoustwo—phaseextraction．Itprovidesbasedataforthe

4、researchofphase—formingmechanismofATPSandapplicationinextraction．Lyciumbarbarumpolysaccharides，akindofmacromoleculecomposedbymultiplemonosaccharides，extractedfromlyceumbarbarumL．，isaveryimportantactivesubstanceinlyceumbarbarumL．．1yciumbarbarumpolysaccharidespossessgoodhealthyandmedicinalvalueforhu

5、manbeingsandhasalargevarietyofbeneficialeffectsinenhancingimmunity,anti—aging，protectingliver,reducingbloodglucoseandfat，resistingtumor．However,itisalwaysahottopicsinresearchofextractinglyciumbarbarumpolysaccharidefieldthathowtoaccomplishtheextractionintegralltyandefficiently．Inthiswork，polymer-sa

6、ltATPSwereapplied，andthephase—formingabilityofsubstancesandtheinfluencingfactorswasdiscussedtoprovidingthetheorybasisforapplicationinextraction．Inaddition，theselectivedistributionbehavioroftargetproductsinfluencingbyvariousfactorswasdiscussed，andtheoptimalextractionconditionswerebuilt．Concretecont

7、entisaslistedbelow：(1)Thebinodalcurvesandtie—linecompositionsofATPSformedbydifferentmolarmassofpoly(ethyleneglyc01)(PEG)andsaltsweremeasuredat25℃，聚合物．盐双水相体系液液相平衡及其在枸杞多糖分离纯化中的应用respectively．Andthesedatawerefittedb