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1、超声造影在常规超声检查阴性的前列腺癌穿刺活检中的应用价值王尧黄品同刘春媚张旭(浙江大学医学院附属第二医院超声科浙江杭州310009)【摘要】冃的:探讨经直肠超声造影靶向引导穿刺在TRUS未发现病灶的可疑前列腺癌患者屮的临床应用价值。方法:对64例血清前列腺特异抗原(PSA)升高(≥4.00ng/ml)且TRUS检查未发现病灶的患者进行经直肠超声造影(CE・TRUS))检查,检查后即刻在TRUS引导下,对每位患者前列腺的双侧底部、屮部的内、外侧区和双侧前列腺尖部行10点系统穿刺以及CE-TRUS发现的异常区域行
2、靶向穿刺,以穿刺病理结果为金标准,统计分析CE-TRUS图像结果和病理结果。结果:64例患者共穿刺701针,病理诊断前列腺癌14例(21.9%),共80针(11.4%)。CE-TRUS发现异常者22例,其中前列腺癌9例,CE-TRUS诊断前列腺癌的敏感性、特异性、准确性分别为64.2%(9/14)、74.0%(37/50)、71.8%(46/64);CE-TRUS靶向穿刺点的单针阳性率(50.8%)高于系统穿刺的(7.7%)(P<0.05);CE-TRUS靶向穿刺检出癌灶的平均Gleason分值与系统穿刺活检
3、检出癌灶平均Gleason分值Z间无显著差异。结论:CE-TRUS技术有助于前列腺癌灶的检出,与系统穿刺法相比,CE-TRUS引导靶向穿刺法有更好的单针阳性率,但在病人检出率上,仍无法取代系统穿刺法。【关键词】超声检查造影剂活组织检查前列腺肿瘤【中图分类号】R730.4【文献标识码】A【文章编号】2095-1752(2014)18-0063-02Significaneeofcontrast-enhancedtransrectalultrasonographyforthedetectionofprostatecanc
4、erinpatientswithnegativefindingsbytransrectalultrasonographyWangYao,HuangPintong,LiuChunmei,ZhangXuDepartmentofUltrasonography,TheSecondAffiliatedHospital,SchoolofMedcine,ZhejiangUniversity,Hangzhou,ZhejiangProvince,310009,China【Abstract]Objective:Toevaluateth
5、evalueofcontrast-enhancedtransrectalultrasonography(CE-TRUS)indetectingprostatecancerinpatientswithnegativefindingsbytransrectalultrasonography(TRUS).Methods:Sixty-fourpatientswithelevatedserumprostate-specificantigen(PSA)levels(morethan4.00ng/mL)butnoabnormal
6、findingsbyTRUSwereevaluatedwithcontrast-enhaneedtransrectalultrasonography(CE-TRUS),a10-coresystematicbiopsy(SB)wassubsequentlytakenatthebase,themidandtheapexglandandthetargetedbiopsy(TB)wastakenatthefocifoundbyCE-TRUSineachpatient.DiagnoSticefficiencyofCE-TRU
7、Sforthecancerdetectionwasevaluated.Cancerdetectionratesbythetwotechniqueswasalsocompared・Results:Prostatecancerwasdetectedin80(11.4%)of701coresin14(21.9%)of64patients.22PatientsshowedabnormalimageinCE-TRUSand9patientswerediagnosedwithprostatecancer,Thesensitiv
8、ity,specificityandoverallaccuracyforthedetectionofprostatecancerbyCE-TRUSwere77.1%,78.2%and77.8%.Positivebiopsycoresweremorefrequentlyobtainedin31of61(50.8%)TBcorescomparedto49of64